1. DeSousa KA, Chandran RJWJA. Intrathecal morphine for postoperative analgesia: current trends. world Journal of Anesthesiology. 2014;3(3):191-202. https://doi:10.5313/wja.v3.i3.191
2. Sultan P, Gutierrez MC, Carvalho BJD. Neuraxial morphine and respiratory depression. 2011;71(14):1807-19. https://doi:10.2165/11596250-000000000-0000
3. Gehling M, Luesebrink T, Kulka P, Tryba MJEJoA. The effective duration of analgesia after intrathecal morphine in patients without additional opioid analgesia: a randomized double-blind multicentre study on orthopaedic patients. European Journal of Anaesthesiology. 2009;26(8):683-8. https://doi:10.1097/EJA.0b013e328329b045
4. Mugabure BB. An Update on Neuraxial Opioid Induced Pruritus Prevention. Journal of Anesthesia & Critical Care: Open Access. 2016;6(2):00226. https://doi:10.15406/jaccoa.2016.06.00226
5. Hess SR, Lahaye LA, Waligora AC, Sima AP, Jiranek WA, Golladay GJJEJoOS, et al. Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty. European Journal of Orthopeadic Surgery & Traumatology. 2019;29(1):125-9. https://doi:10.1007/s00590-018-2293-9
6. Ruan X. Drug-related side effects of long-term intrathecal morphine therapy. Pain Physician. 2007;10(2):357.
7. Hassett P, Ansari B, Gnanamoorthy P, Kinirons B, Laffey JG. Determination of the efficacy and side-effect profile of lower doses of intrathecal morphine in patients undergoing total knee arthroplasty. BMC Anesthesiology. 2008;8(1):5. https://doi:10.1186/1471-2253-8-5
8. Gehling M, Tryba M. Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a meta-analysis. Journal of the Association of Anesthesia of Great Britain and Ireland. 2009;64(6):643-51. https://doi:10.1111/j.1365-2044.2008.05817.x
9. Pathonsamit C, Onklin I, Hongku N, Chaiyakit PJAt. Randomized Double-Blind Controlled Trial Comparing 0.2 mg, 0.1 mg, and No Intrathecal Morphine Combined With Periarticular Injection for Unilateral Total Knee Arthroplasty. Arthroplsty Today. 2021;7:253-9. https://doi:org/10.1016/j.artd.2020.11.008
10. Slappendel R, Weber EW, Dirksen R, Gielen MJ, van Limbeek J, Analgesia. Optimization of the dose of intrathecal morphine in total hip surgery: a dose-finding study. J Anesthesia
1999;88(4):822-6. https://doi:10.1097/00000539-199904000-00026
11. Murphy P, Stack D, Kinirons B, Laffey JJA, Analgesia. Optimizing the dose of intrathecal morphine in older patients undergoing hip arthroplasty. Anesthesia and analgesia. 2003;97(6):1709-15. https://doi:10.1213/01.ane.0000089965.75585.0d
12. Kwan A, Lee B, Brake T. Intrathecal morphine for post-operative analgesia in patients with fractured hips. Hong Kong Medical Journal. 1997;3:250-5.
13. Hospital CHBA. 2020 [Available from: http://www.chrishanibaragwanathhospital.co.za.
14. Rathmell JP, Pino CA, Taylor R, Patrin T, Viani BA. Intrathecal morphine for postoperative analgesia: a randomized, controlled, dose-ranging study after hip and knee arthroplasty. Anesthesia and analgesia. 2003;97(5):1452-7. https://doi:10.1213/01.ane.0000083374.44039.9e
15. Bowrey S, Hamer J, Bowler I, Symonds C, Hall J. A comparison of 0.2 and 0.5 mg intrathecal morphine for postoperative analgesia after total knee replacement. Anaesthesia. 2005;60:449-52. https://doi:10.1111/j.1365-2044.2005.04174.x
16. Rojas A, Hernández M, Vidal P, Balkenhol M, Opazo M, Riquelme M, et al. Low dose intrathecal morphine for hip arthroplasty. Revista Chilena de Anestesia. 2020;49:153-60. https://doi:org/10.25237/revchilanestv49n04-11
17. Cheah JW, Sing DC, Hansen EN, Aleshi P, Vail TP. Does intrathecal morphine in spinal anesthesia have a role in modern multimodal analgesia for primary total joint arthroplasty? The Journal of arthroplasty. 2018;33(6):1693-8. https://doi:10.1016/j.arth.2018.01.016
18. Salmon P, Hall GM, Peerbhoy D, Shenkin A, Parker C, Rehabilitation. Recovery from hip and knee arthroplasty: Patients' perspective on pain, function, quality of life, and well-being up to 6 months postoperatively. Archives of Physical Medicine Rehabilitation 2001;82(3):360-6. https://doi:10.1053/apmr.2001.21522
19. Ko S, Goldstein DH, VanDenKerkhof EG. Definitions of “respiratory depression” with intrathecal morphine postoperative analgesia: a review of the literature. Canadian Journal of Anaesthesia. 2003;50(7):679-88. https://doi:10.1007/BF03018710
20. Cole PJ, Craske DA, Wheatley RG. Efficacy and respiratory effects of low‐dose spinal morphine for postoperative analgesia following knee arthroplasty. BJA: British Journal of Anaesthesia. 2000;85(2):233-7. https://doi:10.1093/bja/85.2.233
21. Gwirtz KH, Young JV, Byers RS, Alley C, Levin K, Walker SG, et al. The safety and efficacy of intrathecal opioid analgesia for acute postoperative pain: seven years' experience with 5969 surgical patients at Indiana University Hospital. Anesthesia and analgesia 1999;88(3):599-604. https://doi:10.1097/00000539-199903000-00026
22. Bailey PL, Rhondeau S, Schafer PG, Lu JK, Timmins BS, Foster W, et al. Dose-response pharmacology of intrathecal morphine in human volunteers. The Journal of the American Society of Anesthesiologists
1993;79(1):49-59. https://doi:10.1097/00000542-199307000-00010
23. Kafer ER, Brown JT, Scott D, Findlay JWA, Butz RF, Teeple E, et al. BIPHASIC DEPRESSION OF THE MINUTE VENTILATION RESPONSE TO CO 2FOLLOWING EPIDURAL MORPHINE. Anesthesiology. 1982;57(3):A482-A. https://doi:10.1097/00000542-198209001-00482
24. Abboud TK, Moore M, Zhu J, Murakawa K, Minehart M, Longhitano M, et al. Epidural butorphanol or morphine for the relief of post-cesarean section pain: ventilatory responses to carbon dioxide. Anesthesia and analgesia. 1987;66(9):887-93.