A pilot study of the Safety First: Real Drug Education for Teens curriculum showed significant results pre to post with high school freshmen. Negative outcomes of drug education are linked to failure to engage students because of developmentally inappropriate material or activities are too unrelated to young people to be meaningful. A few harm reduction studies showed significant increase in student's drug related knowledge. Students were less likely to consume substances and less likely to consume to harmful levels. More studies are necessary to evidence harm reduction efficacy in the classroom. The goal of this study was to measure harm reduction knowledge, attitude and behaviors, including drug policy advocacy, before and after Safety First. Data was analyzed using AVOVA, linear regression, t-tests and thematic coding. Survey results, corroborated by the qualitative findings, showed a significant change (p <.05) in high school freshmen knowledge, attitudes and behaviors in relationship to substance use pre to post class. These findings have implications for replication of the curriculum to other sites. Institutional Review Board approval was granted before the study was conducted with human subjects. The file number is 2017-0746. The date of initial registration was June 29 th , 2017, and continued approval has been granted through August 8 th , 2022.