1 Driver, J. A. Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence. Biogerontology15, 547-557 (2014).
2 Papin, S. & Paganetti, P. Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer. Brain Sciences10, 862 (2020).
3 Xiao, H. et al. Impact of comorbidities on prostate cancer stage at diagnosis in Florida. American journal of men's health10, 285-295 (2016).
4 Snyder, H. M. et al. Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation. Alzheimer's & Dementia13, 267-273 (2017).
5 Zuber, V. et al. Identification of shared genetic variants between schizophrenia and lung cancer. Scientific reports8, 1-8 (2018).
6 Nakanishi, A., Minami, A., Kitagishi, Y., Ogura, Y. & Matsuda, S. BRCA1 and p53 tumor suppressor molecules in Alzheimer’s disease. International journal of molecular sciences16, 2879-2892 (2015).
7 Guo, X. et al. Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration. The Journal of clinical investigation123, 5371-5388 (2013).
8 Jembrek, M. J., Slade, N., Hof, P. R. & Šimić, G. The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease. Progress in neurobiology168, 104-127 (2018).
9 Campbell, W. A. et al. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen‐2) demonstrate excessive p53‐dependent apoptosis and neuronal loss. Journal of neurochemistry96, 1423-1440 (2006).
10 Gandhi, S. & Wood, N. W. Molecular pathogenesis of Parkinson's disease. Human molecular genetics14, 2749-2755 (2005).
11 Aubrey, B. J., Kelly, G. L., Janic, A., Herold, M. J. & Strasser, A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death & Differentiation25, 104-113 (2018).
12 Kung, C.-P. & Murphy, M. E. The role of the p53 tumor suppressor in metabolism and diabetes. The Journal of endocrinology231, R61 (2016).
13 Zhang, C.-g., Wan, H.-q., Ma, K.-n., Luan, S.-x. & Li, H. Identification of biomarkers related to neuropathic pain induced by peripheral nerve injury. Journal of Molecular Neuroscience69, 505-515 (2019).
14 Szybińska, A. & Leśniak, W. P53 dysfunction in neurodegenerative diseases-the cause or effect of pathological changes? Aging and disease8, 506 (2017).
15 Catts, V. S. et al. Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines. Schizophrenia research84, 20-28 (2006).
16 Gassó, P. et al. Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naïve first-episode schizophrenia patients. Journal of psychiatric research48, 94-101 (2014).
17 Ma, X., Fei, E., Fu, C., Ren, H. & Wang, G. Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Molecular psychiatry16, 1105-1116 (2011).
18 Mao, X. et al. The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. Molecular pharmacology79, 672-680 (2011).
19 Angelucci, F., Brene, S. & Mathe, A. BDNF in schizophrenia, depression and corresponding animal models. Molecular psychiatry10, 345-352 (2005).
20 Huang, H.-J. et al. Ghrelin alleviates anxiety-and depression-like behaviors induced by chronic unpredictable mild stress in rodents. Behavioural brain research326, 33-43 (2017).
21 Ruan, C. S. et al. Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety-and depression-like behaviors. Neuroscience293, 12-22 (2015).
22 Baudry, M. Calpain-1 and Calpain-2 in the Brain: Dr. Jekill and Mr Hyde? Current neuropharmacology17, 823-829 (2019).
23 Martin, H. G. & Wang, Y. T. Blocking the deadly effects of the NMDA receptor in stroke. Cell140, 174-176 (2010).
24 Alsabban, A. H., Morikawa, M., Tanaka, Y., Takei, Y. & Hirokawa, N. Kinesin Kif3b mutation reduces NMDAR subunit NR 2A trafficking and causes schizophrenia‐like phenotypes in mice. The EMBO journal39, e101090 (2020).
25 Woo, T.-U. W., Shrestha, K., Lamb, D., Minns, M. M. & Benes, F. M. N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder. Biological psychiatry64, 803-809 (2008).
26 Merlo, P. et al. p53 prevents neurodegeneration by regulating synaptic genes. Proceedings of the National Academy of Sciences111, 18055-18060 (2014).
27 Turnquist, C. et al. p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration. Cell Death & Differentiation23, 1515-1528 (2016).
28 Morrison, R. & Kinoshita, Y. The role of p53 in neuronal cell death. Cell Death & Differentiation7, 868-879 (2000).
29 Biswas, S. C., Ryu, E., Park, C., Malagelada, C. & Greene, L. A. Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease. Neurochemical research30, 839-845 (2005).
30 Vesce, S., Rossi, D., Brambilla, L. & Volterra, A. Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. International review of neurobiology82, 57-71 (2007).
31 Harrison, P. J., Hall, N., Mould, A., Al-Juffali, N. & Tunbridge, E. M. Cellular calcium in bipolar disorder: systematic review and meta-analysis. Molecular psychiatry, 1-11 (2019).
32 Casamassima, F. et al. L‐type calcium channels and psychiatric disorders: A brief review. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics153, 1373-1390 (2010).
33 Einat, H., Karbovski, H., Korik, J., Tsalah, D. & Belmaker, R. Inositol reduces depressive-like behaviors in two different animal models of depression. Psychopharmacology144, 158-162 (1999).
34 Yamamoto, T. & Takahara, A. Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Current topics in medicinal chemistry9, 377-395 (2009).
35 Terasaki, Y. et al. Activation of NR2A receptors induces ischemic tolerance through CREB signaling. Journal of Cerebral Blood Flow & Metabolism30, 1441-1449 (2010).
36 Singh, A. K. et al. Neuroprotection through rapamycin-induced activation of autophagy and PI3K/Akt1/mTOR/CREB signaling against amyloid-β-induced oxidative stress, synaptic/neurotransmission dysfunction, and neurodegeneration in adult rats. Molecular neurobiology54, 5815-5828 (2017).
37 Seinfeld, J., Baudry, N., Xu, X., Bi, X. & Baudry, M. Differential activation of calpain-1 and calpain-2 following kainate-induced seizure activity in rats and mice. Eneuro3 (2016).
38 Miao, Y. et al. Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons. (2012).
39 Almeida, R. et al. Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death & Differentiation12, 1329-1343 (2005).
40 Dong, Y. et al. Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons. BMC neuroscience19, 1-8 (2018).
41 Zipp, F. & Aktas, O. The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends in neurosciences29, 518-527 (2006).
42 Heneka, M. T. et al. Neuroinflammation in Alzheimer's disease. The Lancet Neurology14, 388-405 (2015).
43 Lin, T. et al. Emerging roles of p53 related lncRNAs in cancer progression: a systematic review. International journal of biological sciences15, 1287 (2019).
44 Hwang, C. J. et al. Reducing effect of IL-32α in the development of stroke through blocking of NF-κB, but enhancement of STAT3 pathways. Molecular neurobiology51, 648-660 (2015).