Talus slope are widely distributed all over the world, which is a special natural landscape and widely distributed in southwest and Northeast China particularly. It’s formed by the collapse and transportation of parent rock, freeze-thaw cracking and other reasons, so it’s often loosely accumulated at the foot of the hillside or at the gentle hillside. They are usually composed of collapsed rockfalls and weathered soil mixtures with large particle sizes. Therefore, Tunnel excavation construction through blasting will directly threaten the construction and operation safety of Railway, Highway and other projects along the way, which is very easy to cause heavy economic and personnel losses. In order to explore the dynamic response mechanism of overlying loose talus slope affected by blasting construction, taking the blasting excavation of Daqianshiling talus slope as an example, we measured the size of rocks on the slope on site, carried out the on-site and indoor geotechnical tests, and monitored the velocity and acceleration in real time. Then, we constructed the two dimensional particle discrete element model of irregular rock under blasting, which calibrated based on macro mechanical parameters obtained from field measurements. On this basis, we studied the process of rock breaking by blasting, the dynamic response law of slope, the propagation law of stress wave reflected and an interesting phenomena, eddy current phenomenon, by the the numerical simulation. Finally, we verified the applicability and limitation of Sadovsky family formulas for talus slope under blasting. This research is conducive to controlling blasting parameters and safe construction.