Purpose: To determine the comparison of the optical biometric measurements using optical biometry in patients with previously received COVID-19 treatment and the control group.
Methods: In this cross-sectional study, the COVID-19 was diagnosed by polymerase chain reaction test, clinical signs and radiologic findings. Patients with previously received COVID-19 treatment was determined as COVID-19 group and the age and sex-matched healthy subjects were served as control group. The optical biometric measurements including corneal astigmatism, keratometry, astigmatic axis, central corneal thickness, anterior chamber depth and axial length were obtained using Nidek optical biometry (AL-Scan; Nidek Co., Ltd., Japan).
Results: The measurements of keratometry(p=0,47), corneal astigmatism(p=0,42), axial length(p=0,78), anterior chamber depth(p=0,46) and central corneal thickness(p=0,43) were similar between the COVID-19 and control groups. The astigmatic axis type taken from 2.4 mm of the cornea showed statistically significant difference between two groups (p=0,01), while the measurements taken from 3 mm of the cornea were similar(p=0,15). In the subgroup analysis, axial lenght, anterior chamber depth and central corneal thickness measurements were found statistically significantly higher in the male gender of the COVID-19 group (p= 0,03; p= 0,01; p=0,03, Mann Whitney U).
Conclusion: Changing in the optical biometric measurements can be seen as a result of the fact that COVID-19 is more frequent and severe in male gender and SARS-CoV-2 can attach to the cornea via ACE-2 receptors. To our knowledge, there is no study about this subject yet and conducting research with other studies on this issue will provide a better enlightenment about this subject.