Taking 110 prefecture level cities in the Yangtze River economic belt from 2008 to 2017 as samples, uses SBM model, coupling coordination model and panel VAR model to study the interaction between urban land price and urban land use efficiency, in order to reveal the interactive influence differences between urban land price and land use efficiency in the region, so as to provide reference for land use management and mitigation in the region Contradiction provides reference. The results are as follows: (1) there is a two-way causal relationship between urban land price and urban land use efficiency in all types of cities, but there are regional differences in the level of significance; (2) the urban land use efficiency and land price in all types of cities have self enhancement mechanism, but they weaken over time; (3) the land price in all types of cities can be increased to a certain extent urban land use efficiency, but the improvement of different types of urban land use efficiency does not necessarily lead to the rise of land price; and (4) different types of urban land use efficiency and the ability of self-inertia enhancement of land price are different, and the mutual influence intensity between land price and land use efficiency is also different. Conclusion: The interaction between land price and land use efficiency is different in different coupling cities. In order to improve the regional land use efficiency and ease the contradiction of land use, we should make different management strategies based on the interaction between them.