Ethics approval and consent to participate
All animal experiments were conducted in accordance with Guide for the Care and Use of Laboratory Animals and approved by the Institutional Animal Care and Use Committee (IACUC) of National Yang-Ming University (IACUC number: 1081012). No human data were used for this study, and thus consent was not required.
Consent for publication
No human data were used for this study, and thus consent was not required.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
The authors declare that they have no competing interests.
This research was supported by funding from Ministry of Science and Technology (MOST 105-2628-B-010-010-MY3 and MOST 108-2320-B-010 -043 -MY3) (Y.I.C.), a grant from Yen Tjing Ling Medical Foundation (CI-109-6). (Y.I.C.) This work is particularly supported by "Yin Yen-Liang Foundation Development and Construction Plan" of the School of Medicine, National Yang-Ming University (Y.I.C.).
CYT performed the experiments about DEHP in survival and differentiation in cell lines and identifying molecular mechanism, data analysis, and manuscript writing. TPF performed the analysis of OCR and ECAR and the identification of molecular mechanism, data analysis, and manuscript writing. YIC performed colony forming assay. SWC, HWC, ECYL and TAL participated in parts of experiments and supervised the animal harvest and care. TAL, DCT and YIC conceived and designed the study. YIC supervised the project, edited the manuscript and gave approval to its final version. All authors read and approved the final manuscript.
We are grateful to Dr. Tzong-Shyuan Lee (National Taiwan University, Taiwan) for providing DEHP. We thank the Instrumentation Research Center of National Yang-Ming University (Taiwan) for use of the shared services to complete this research. We also thank the National RNAi Core Facility at Academia Sinica in Taiwan for providing shRNA reagents and related services.
1Department and Institute of Physiology, National Yang-Ming University, No. 155, Sec. 2, Linong St., Taipei City 112304, Taiwan. 2Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei 112201, Taiwan. 3Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei 112201, Taiwan. 4Institute of Clinical Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Taipei 112304, Taiwan. 5Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), No. 1001, University Rd., Hsinchu City 300093, Taiwan.