Studies of properties of PO catalysts and reaction parameters
Guided by the hypothesis, we first focused on the selective defluoroalkylation of trifluoroacetamide with alkenes, a transformation that has not been successfully developed using photocatalysis. We discovered that a catalytic amount of PO in combination with 1-adamatanethiol (1-AdSH) as the HAT catalyst in the presence of formate catalyzed monoselective defluoroalkylation of N-phenyltrifluoroacetamide with alkenes under irradiation with a 427 nm LED (Kessil®, emission FWHM of approximately 20 nm).35 A similar transformation was reported by Houk and Wang et al. under thermal conditions using a stoichiometric amount of DMAP-BH3 via a spin-center shift strategy.36 Fig. 2 shows the key reaction parameters. Under optimal conditions (Fig. 2a), defluoroalkylation product (3) was obtained in 90% yield determined by 1H-NMR, along with the generation of 4 in 5 % yield. The reaction mixture appeared as a light yellow homogeneous solution, suggesting its promising applications in flow photosynthesis.37-38 UV-Vis absorption spectra of catalysts, substrates, and reaction mixtures were measured to determine the light absorbing species (Fig. 2b). Both substrates (1 and 2) absorb light only in the ultraviolet range (< 325 nm). PO1 in its phenol form had an absorption onset at approximately 370 nm (purple line in Fig. 2b). Upon mixing with Cs2CO3, the deprotonated anion of PO1 (PO1–) exhibited redshifted absorption into the visible light range with an absorption onset at approximately 425 nm. Comparison of the absorption spectra of PO1– and tert-butylphenolate showed that the ortho-PPh2 substituent significantly redshifted the absorption curve by approximately 70 nm (see Supplementary Information for details). PO1– absorbs visible light with an onset at approximately 425 nm and shows an emission maximum at 540 nm. The reduction potential of excited PO1– (*PO1–) is estimated to be –2.89 V vs. SCE, a value sufficient to reduce a broad scope of trifluoromethyl aromatic and carbonyl compounds (PhCF3, Ered1/2 = –2.50 V vs. SCE in DMF;18 CF3COOEt, Eredp/2 = –2.40 V vs. SCE) (see Supplementary Information S41, for details). Anions generated by the deprotonation of amide 1 maximally absorb light until 350 nm. In the presence of 1, the absorption spectrum of PO1– did not show a bathochromic shift, showing that an electron-donor-acceptor complex39-41 between 1 and PO1– was not formed (blue line). The absorption curve of the reaction mixture (red line) was identical to that of PO1–, indicating that PO1– was the light absorbing species in the reaction mixture. Fig. 1c shows the PO catalysts with different structures. 2-Methyl (PO2)-, 2,4-di-tert-butyl (PO3)-, and 2,4-dimethyl (PO4)-substituted o-phosphinophenols all showed performances comparable to that of PO1. o-Phosphinophenol (PO5) without a p-substituent showed reduced catalytic efficacy. p-Phosphinophenol (PO6) gave 3 in only 15% yield, which suggests the essential role of intramolecular P–O interactions in catalytic efficacy. A bulky PO catalyst with a dicyclohexylphosphine substituent (PO7) was ineffective. Regarding to stability, PO1 is bench-stable white powder and can be stored under ambient air for months without apparent decomposition and oxidation.
Table 1 summaries key reaction parameters. Using cyclohexanethiol as the HAT catalyst reduced the yield (entry 1, Table 1). Using 10 mol % 1-AdSH resulted in decreased yield (entry 2). PO1 (2 mol %) still catalyzed the reaction in 52% yield (entry 3). Increasing the amount of alkene to 2.0 equivalents suppressed hydrodefluorination and increased the defluoroalkylation yield to 96%. Replacing formate with triethylsilane gave 2 in 30% yield (entry 5), indicating that formate is not essential for C–F activation. LEDs with an emission peak at 440 nm (emission range from 415 nm to 470 nm) also promoted the reaction (entry 6), but LEDs with emission peaks at 456 nm and 467 nm, which did not overlap with the absorption of PO1–, were ineffective (entries 7 and 8). PPh3 and 4-tert-butylphenol used alone were both ineffective (entries 9 and 10), while 10% of 3 was generated by using a mixture of them (entry 11), suggesting certain role of P–O interactions in efficient photoelectron transfer. Control experiments showed that PO1, 1-AdSH, and light were all essential parameters (entries 12, 13, 15). In the absence of formate salt, product 3 was detected in 18% yield (entry 14), suggesting the role of formate in catalyst turnover (ref. Figure 1c). The cation moiety of formate salt affects not only solubility but also reactivity, because the alkali metal cations act as counter cations of both formate and generated fluoride salt, that may affect the rates of HAT and defluorination. Hence, different formate salts (Li, Na, K, Cs) were tested (see Supplementary Table 1 in SI page 6 for details). The quantum yield of 3 was estimated to be 4.4 according to the literature,42-43 which suggested that CO2•– generated after HAT may activate –CF3 substrates (e.g. reduction potential of 1,3-bistrifluoromethylbenzene, Ered1/2 = –2.07 V vs. SCE; reduction potential of 1, Eredp/2 = –2.11 V vs. SCE) in relay with the thiol HAT catalyst to deliver 3 (pale dashed arrow in Figure 1c).44-45 Exposure to air completely killed the catalytic reactivity (entry 16) resulting recovery of starting materials, as air can quench excited triplet state of PO1– and oxidize thiol.
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)
Scope of the reactions
Fig. 3 illustrates the scope of the defluoroalkylation of trifluoroacetamides. The reaction can be easily scaled up to the gram scale under batch conditions using Kessil LEDs and a Schlenk flask (3). For trifluoroacetamides possessing electron-neutral and electron-rich N-aryl substituents, monodefluoroalkylation products accompanied by a small amount of hydrodefluorination byproduct (5 – 10%) were obtained (5, 6, 7). For trifluoroacetamides with strong electron-deficient N-aryl substituents, products of didefluoroalkylation were obtained as major products (8, 9), and monodefluoroalkylation products were observed only in trace amounts (< 3%). The recovered amide staring materials accounted for moderate yields (8, 9). For N-3-pyridyl trifluoroacetamide (10), a monodefluoroalkylation product was obtained in 68% yield.
An N-aryl substituent is essential for defluoroalkylation (13, 14), and the reactivity is not applicable to tertiary amides (12). Measuring reduction potentials of different trifluoroacetamides by cyclic voltammetry revealed that N-phenyltrifluoroacetamide (1) is thermodynamically easier to reduce (Eredp/2 = –2.11 V vs. SCE) than N-benzyltrifluoroacetamide (Eredp/2 = –2.56 V vs. SCE) and primary trifluoroacetamide (Eredp/2 = –2.49 V vs. SCE). We also rationalize that N-aryl substituent stabilizes amide radical anion through charge delocalization, thus suppresses back electron transfer with PO• to facilitate subsequent cleavage of C–F bond. The reaction tolerates a broad scope of aliphatic alkenes (15, 16, 18, 19), including sterically hindered internal alkenes (17) and cyclic alkenes (20). β-Pinene gave ring-opened product (21) in high yield. Allylic-type substrates were also amenable, as allylic silane (22), allylic boronate (23), allylic amine (24), and allylic acetate (25) all reacted well. The amenable alkenes also include vinyl-type substrates. Vinyl acetates (26, 27) are suitable substrates. Hydrolysis of defluoroalkylation products with vinyl acetates can provide fluorinated and methylated γ-hydroxybutyrate (26, 27), which is an active component of XYREM, a drug approved by the FDA to treat symptoms of narcolepsy.46 Vinyl silane (28), vinyl ether (29), N-vinyl amide (30), and vinyl carbazole (31) all reacted effectively. However, styrene- and acrylate-type substrates were unsuitable, probably because of the facile addition of these types of alkenes with CO2•– under the reaction conditions.47-48 In addition to trifluoroacetamides, trifluoroacetates also reacted in high yield to provide α,α-difluorinated aliphatic carboxylate esters (Fig. 4, 32–35).
In the absence of an alkene, hydrodefluorination products were generated (Fig. 5). Thiol as a polarity reversal catalyst34 is essential for a high yield of hydrodefluorination. Cesium formate used in 1.2 equivalents is critical to ensure high monoselectivity (4, 36–39). The N-phenyltrifluoroacetamide with a para-ester substituent underwent thorough hydrodefluorination to generate acetamide (40). The same reaction conditions are also applicable to the selective hydrodefluorination and defluoroalkylation of pentafluoropropionamide (eq. 1 and eq. 2 in Scheme 1), suggesting the further application of PO catalysts in the selective C–F functionalization of polyfluorinated compounds (41, 43).49-51
In Fig. 6, the application of PO1 as a catalyst for defluoroalkylation of trifluoromethyl arenes and heteroarenes is demonstrated. Lithium formate was found to be the hydrogen donor of choice, and DMSO was found to be the preferred solvent. The monoselective defluoroalkylation reaction is applicable to a broad scope of trifluoromethyl arenes, including both di-CF3 substituted arenes and mono-CF3 substituted arenes. Potassium tert-butoxide was found to be a better base for di-CF3 arenes than cesium carbonate because it resulted in high selectivity (44, 45, 46, 48, 49). Although trifluoromethylbenzene was an unsuitable substrate (< 15% conversion), m-methoxy-substituted trifluoromethylbenzene reacted in 50% yield (50). m-CF3-substituted phenylboronate reacted in 78% to give fluorinated building blocks useful in cross-coupling reactions (51). Pyridine derivatives bearing –CF3 at both the 2- and 3-positions reacted smoothly, generating valuable α,α-difluoroalkylated pyridines (52, 53). For alkene scope, in addition to vinyl silane (54) and aliphatic alkene (57), acetals of acrylaldehyde (55), vinyl ethylene carbonate (56), N-vinylpyrrolidinone (58), and 2-vinyloxytetrahydropyran (59) all reacted smoothly. An FDA-approved antipsychotic drug for schizophrenia, trifluoperazine (Stelazine®), was selectively defluoroalkylated (60), showcasing the practical utility for late-stage functionalization of CF3-containing drugs. Monoselective hydrodefluorination of trifluoromethyl arene could also be achieved in the absence of alkene (61, eq. 3 in Scheme 2).