Table 1 Numbers of participants in the control group, the 1st and 8th year of the follow-up group
Age group
|
≤30y
|
31-40y
|
41-50y
|
51-60y
|
61-70y
|
≥71y
|
Total
|
The control group
|
|
|
|
|
|
|
|
2012
|
Male
|
1901
|
2090
|
1868
|
1759
|
682
|
510
|
8810
|
|
Female
|
2446
|
2067
|
2490
|
1911
|
789
|
598
|
10,301
|
2013
|
Male
|
1870
|
2365
|
1801
|
1687
|
774
|
598
|
9095
|
|
Female
|
2731
|
2508
|
2078
|
1757
|
800
|
600
|
10,474
|
2014
|
Male
|
1473
|
2138
|
1571
|
1605
|
773
|
563
|
8123
|
|
Female
|
2132
|
2444
|
1965
|
1769
|
831
|
602
|
9743
|
2015
|
Male
|
1044
|
1751
|
1431
|
1603
|
799
|
509
|
7137
|
|
Female
|
1859
|
2383
|
1850
|
1723
|
933
|
606
|
9354
|
2016
|
Male
|
1207
|
1946
|
1428
|
1629
|
888
|
551
|
7649
|
|
Female
|
1885
|
2437
|
1836
|
1710
|
1050
|
644
|
9562
|
2017
|
Male
|
1121
|
1714
|
1278
|
1276
|
786
|
408
|
6583
|
|
Female
|
1613
|
2236
|
1752
|
1419
|
958
|
570
|
8548
|
2018
|
Male
|
1248
|
1850
|
1283
|
1236
|
832
|
424
|
6873
|
|
Female
|
1852
|
2435
|
1820
|
1465
|
1082
|
550
|
9204
|
2019
|
Male
|
980
|
1846
|
1413
|
1263
|
815
|
371
|
6688
|
|
Female
|
1508
|
2689
|
1793
|
1297
|
1034
|
529
|
8850
|
The follow-up group
|
|
|
|
|
|
|
|
1st
|
Male
|
197
|
403
|
418
|
417
|
205
|
115
|
1755
|
|
Female
|
521
|
830
|
794
|
673
|
279
|
191
|
3288
|
8th
|
Male
|
28
|
300
|
398
|
404
|
403
|
222
|
1755
|
|
Female
|
73
|
700
|
818
|
713
|
625
|
359
|
3288
|
Table 2 The levels of serum lipids and glucose in the control group
<tr>
<td rowspan="2" width="5.368421052631579%">
<p>Age group</p>
</td>
<td colspan="2" width="17.57894736842105%">
<p>TG</p>
</td>
<td width="1.6842105263157894%">
<p> </p>
</td>
<td colspan="2" width="17.57894736842105%">
<p>TC</p>
</td>
<td width="1.6842105263157894%">
<p> </p>
</td>
<td colspan="2" width="17.57894736842105%">
<p>LDL-C</p>
</td>
<td width="1.6842105263157894%">
<p> </p>
</td>
<td colspan="2" width="17.57894736842105%">
<p>HDL-C</p>
</td>
<td width="1.6842105263157894%">
<p> </p>
</td>
<td colspan="2" width="17.57894736842105%">
<p>GLU</p>
</td>
</tr>
<tr>
<td width="8.960176991150442%">
<p>Male</p>
</td>
<td width="9.623893805309734%">
<p>Female</p>
</td>
<td width="1.7699115044247788%">
<p> </p>
</td>
<td width="8.960176991150442%">
<p>Male</p>
</td>
<td width="9.623893805309734%">
<p>Female</p>
</td>
<td width="1.7699115044247788%">
<p> </p>
</td>
<td width="8.960176991150442%">
<p>Male</p>
</td>
<td width="9.623893805309734%">
<p>Female</p>
</td>
<td width="1.7699115044247788%">
<p> </p>
</td>
<td width="8.960176991150442%">
<p>Male</p>
</td>
<td width="9.623893805309734%">
<p>Female</p>
</td>
<td width="1.7699115044247788%">
<p> </p>
</td>
<td width="8.960176991150442%">
<p>Male</p>
</td>
<td width="9.623893805309734%">
<p>Female</p>
</td>
</tr>
<tr>
<td width="5.340314136125654%">
<p>≤30y</p>
</td>
<td width="8.481675392670157%">
<p>1.05</p>
<p>(0.72-1.60)</p>
</td>
<td width="9.109947643979057%">
<p>0.67</p>
<p>(0.51-0.92)<sup>#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>4.47</p>
<p>(3.95-5.06)</p>
</td>
<td width="9.109947643979057%">
<p>4.31</p>
<p>(3.86-4.80)<sup>#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>2.78</p>
<p>(2.31-3.30)</p>
</td>
<td width="9.109947643979057%">
<p>2.45</p>
<p>(2.06-2.87)<sup>#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>1.20</p>
<p>(1.01-1.42)</p>
</td>
<td width="9.109947643979057%">
<p>1.56</p>
<p>(1.33-1.80)<sup>#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>4.96</p>
<p>(4.69-5.24)</p>
</td>
<td width="9.109947643979057%">
<p>4.84</p>
<p>(4.59-5.10)<sup>#</sup></p>
</td>
</tr>
<tr>
<td width="5.340314136125654%">
<p>31-40y</p>
</td>
<td width="8.481675392670157%">
<p>1.38</p>
<p>(0.93-2.09)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>0.78</p>
<p>(0.57-1.10)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>4.79</p>
<p>(4.26-5.36)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>4.51</p>
<p>(4.03-5.05)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>3.04</p>
<p>(2.56-3.55)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>2.62</p>
<p>(2.21-3.10)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>1.13</p>
<p>(0.96-1.34)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>1.52</p>
<p>(1.28-1.78)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>5.10</p>
<p>(4.82-5.43)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>4.95</p>
<p>(4.69-5.24)<sup>***</sup><sup>,#</sup></p>
</td>
</tr>
<tr>
<td width="5.340314136125654%">
<p>41-50y</p>
</td>
<td width="8.481675392670157%">
<p>1.49</p>
<p>(1.00-2.22)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>0.95</p>
<p>(0.68-1.39)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>4.94</p>
<p>(4.39-5.54)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>4.86</p>
<p>(4.32-5.43)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>3.13</p>
<p>(2.63-3.67)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>2.94</p>
<p>(2.49-3.46)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>1.15</p>
<p>(0.97-1.37)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>1.49</p>
<p>(1.24-1.76)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>5.31</p>
<p>(4.97-5.77)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>5.11</p>
<p>(4.82-5.44)<sup>***</sup><sup>,#</sup></p>
</td>
</tr>
<tr>
<td width="5.340314136125654%">
<p>51-60y</p>
</td>
<td width="8.481675392670157%">
<p>1.44</p>
<p>(0.99-2.15)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>1.23</p>
<p>(0.86-1.75)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>4.95</p>
<p>(4.34-5.56)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>5.34</p>
<p>(4.73-5.98)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>3.14</p>
<p>(2.58-3.68)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>3.35</p>
<p>(2.80-3.92)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>1.18</p>
<p>(0.99-1.40)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>1.47</p>
<p>(1.23-1.75)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>5.54</p>
<p>(5.12-6.20)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>5.31</p>
<p>(4.99-5.76)<sup>***,#</sup></p>
</td>
</tr>
<tr>
<td width="5.340314136125654%">
<p>61-70y</p>
</td>
<td width="8.481675392670157%">
<p>1.28</p>
<p>(0.91-1.85)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>1.30</p>
<p>(0.93-1.83)<sup>***</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>4.77</p>
<p>(4.13-5.40)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>5.27</p>
<p>(4.66-5.91)<sup>***</sup><sup>,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>2.99</p>
<p>(2.42-3.55)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>3.24</p>
<p>(2.68-3.82)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>1.20</p>
<p>(1.00-1.44)</p>
</td>
<td width="9.109947643979057%">
<p>1.45</p>
<p>(1.21-1.73)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>5.61</p>
<p>(5.17-6.37)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>5.46</p>
<p>(5.10-6.00)<sup>***,#</sup></p>
</td>
</tr>
<tr>
<td width="5.340314136125654%">
<p>≥71y</p>
</td>
<td width="8.481675392670157%">
<p>1.15</p>
<p>(0.82-1.62)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>1.25</p>
<p>(0.91-1.72)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>4.48</p>
<p>(3.88-5.16)</p>
</td>
<td width="9.109947643979057%">
<p>5.00</p>
<p>(4.34-5.69)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>2.76</p>
<p>(2.19-3.36)<sup>*</sup></p>
</td>
<td width="9.109947643979057%">
<p>2.99</p>
<p>(2.38-3.62)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>1.21</p>
<p>(1.01-1.47)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>1.46</p>
<p>(1.21-1.76)<sup>***,#</sup></p>
</td>
<td width="1.675392670157068%">
<p> </p>
</td>
<td width="8.481675392670157%">
<p>5.77</p>
<p>(5.28-6.65)<sup>***</sup></p>
</td>
<td width="9.109947643979057%">
<p>5.66</p>
<p>(5.19-6.45)<sup>***,#</sup></p>
</td>
</tr>
<tr>
<td colspan="15" valign="top" width="100%">
<p><sup>*</sup>: p < 0.05 compared with sex-matched ≤30 year group; <sup>***</sup>: p < 0.001 compared with sex-matched ≤30 year group</p>
<p><sup>#</sup>: p < 0.001 compared with age-matched male</p>
</td>
</tr>
</tbody>
Table 3 Levels of serum TG, TC and GLU in 2019 of the control group, the 1st and 8th year of the follow-up group
Age group
|
≤40y
|
|
41-50y
|
|
51-60y
|
|
61-70y
|
|
≥71y
|
|
|
Male
|
Female
|
|
Male
|
Female
|
|
Male
|
Female
|
|
Male
|
Female
|
|
Male
|
Female
|
TG
|
2019
|
1.25
(0.83-1.94)
|
0.74
(0.55-1.04)
|
|
1.41
(0.97-2.12)
|
0.95
(0.70-1.35)
|
|
1.46
(1.02-2.15)
|
1.22
(0.87-1.76)
|
|
1.26
(0.89-1.81)
|
1.33
(0.93-1.86)
|
|
1.21
(0.81-1.67)
|
1.27
(0.92-1.76)
|
|
1st
|
1.15
(0.79-1.76)
|
0.71
(0.53-0.99)
|
|
1.44
(1.00-2.11)
|
0.97
(0.70-1.39)
|
|
1.44
(1.04-2.05)
|
1.20
(0.85-1.64)
|
|
1.37
(0.93-2.12)
|
1.29
(0.93-1.86)
|
|
1.21
(0.85-1.54)
|
1.27
(0.93-1.74)
|
|
8th
|
1.29
(0.93-2.04)#
|
0.77
(0.58-1.10)*,#
|
|
1.42
(0.96-2.10)
|
0.95
(0.70-1.37)
|
|
1.47
(1.03-2.06)
|
1.23
(0.87-1.69)
|
|
1.27
(0.94-1.82)
|
1.27
(0.92-1.81)
|
|
1.26
(0.83-1.72)
|
1.24
(0.92-1.67)
|
TC
|
2019
|
4.78
(4.23-5.43)
|
4.56
(4.08-5.10)
|
|
5.06
(4.45-5.63)
|
4.99
(4.42-5.54)
|
|
4.98
(4.36-5.63)
|
5.45
(4.85-6.10)
|
|
4.87
(4.12-5.50)
|
5.36
(4.78-6.02)
|
|
4.40
(3.78-5.08)
|
4.98
(4.21-5.60)
|
|
1st
|
4.57
(4.04-5.14)
|
4.35
(3.89-4.92)
|
|
4.86
(4.41-5.44)
|
4.84
(4.27-5.41)
|
|
4.93
(4.34-5.51)
|
5.20
(4.67-5.85)
|
|
4.78
(4.16-5.30)
|
5.17
(4.62-5.77)
|
|
4.42
(3.74-5.16)
|
5.04
(4.37-5.62)
|
|
8th
|
5.04
(4.48-5.60)*,#
|
4.71
(4.23-5.29)*,#
|
|
5.00
(4.44-5.59)
|
5.05
(4.49-5.64)*,#
|
|
4.98
(4.37-5.58)
|
5.49
(4.86-6.10)#
|
|
4.90
(4.17-5.49)
|
5.31
(4.74-5.97)#
|
|
4.35
(3.80-5.03)
|
5.01
(4.26-5.63)
|
GLU
|
2019
|
5.02
(4.75-5.32)
|
4.89
(4.63-5.14)
|
|
5.27
(4.94-5.73)
|
5.06
(4.80-5.39)
|
|
5.49
(5.08-6.18)
|
5.27
(4.95-5.74)
|
|
5.70
(5.23-6.55)
|
5.42
(5.08-5.97)
|
|
5.78
(5.28-.66)
|
5.62
(5.14-6.45)
|
|
1st
|
5.12
(4.81-5.42)
|
5.04
(4.78-5.35)
|
|
5.28
(4.97-5.78)
|
5.17
(4.88-5.51)
|
|
5.50
(5.11-6.10)
|
5.34
(5.02-5.75)
|
|
5.71
(5.27-6.37)
|
5.52
(5.15-6.00)
|
|
5.74
(5.28-6.52)
|
5.71
(5.20-6.41)
|
|
8th
|
5.16
(4.87-5.48)*
|
5.08
(4.81-5.40)*
|
|
5.41
(5.03-5.78)
|
5.20
(4.92-5.53)*
|
|
5.54
(5.16-6.12)
|
5.46
(5.10-5.88)#
|
|
5.75
(5.25-6.62)
|
5.57
(5.18-6.14)*
|
|
5.86
(5.36-6.83)
|
5.78
(5.21-6.67)
|
*: p < 0.001 compared with age-matched group in 2019 of the control group
#: p < 0.001 compared with age-matched group in the 1st year of the follow-up group
|
Table 4 Percentages of hyperlipidemia in the control group from 2012 to 2019
Age group
|
≤40y
|
41-50y
|
51-60y
|
61-70y
|
≥71y
|
Total
|
2012
|
Male
|
19.22
|
29.41
|
26.83
|
17.45
|
12.35
|
22.58
|
|
Female
|
3.99
|
11.73
|
22.50
|
25.22
|
21.07
|
11.91
|
2013
|
Male
|
20.07
|
29.15
|
28.33
|
19.25
|
12.21
|
22.81
|
|
Female
|
4.62
|
11.93
|
25.95
|
27.50
|
23.67
|
12.49
|
2014
|
Male
|
19.44
|
28.26
|
27.73
|
21.73
|
12.61
|
22.53
|
|
Female
|
5.03
|
11.15
|
24.87
|
25.27
|
19.77
|
12.50
|
2015
|
Male
|
19.18
|
26.83
|
26.45
|
17.52
|
14.15
|
21.80
|
|
Female
|
5.02
|
10.16
|
25.42
|
23.69
|
20.63
|
12.67
|
2016
|
Male
|
19.98
|
29.69
|
27.44
|
19.71
|
14.34
|
22.94
|
|
Female
|
6.78
|
12.69
|
29.24
|
28.86
|
24.84
|
15.57
|
2017
|
Male
|
20.11
|
28.40
|
28.13
|
19.97
|
12.75
|
22.80
|
|
Female
|
6.65
|
14.21
|
28.05
|
29.44
|
20.35
|
15.22
|
2018
|
Male
|
18.88
|
24.63
|
24.43
|
18.63
|
13.44
|
20.60
|
|
Female
|
5.95
|
11.37
|
27.37
|
28.19
|
17.45
|
13.73
|
2019
|
Male
|
21.60
|
27.67
|
27.79
|
19.39
|
12.94
|
23.24
|
|
Female
|
6.79
|
14.39
|
30.61
|
29.59
|
20.98
|
15.33
|
Table 5 Percentages of hyperglycemia in the control group from 2012 to 2019
Age group
|
≤40y
|
41-50y
|
51-60y
|
61-70y
|
≥71y
|
Total
|
2012
|
Male
|
1.80
|
8.46
|
14.10
|
16.28
|
20.20
|
7.84
|
|
Female
|
0.64
|
2.37
|
7.12
|
10.39
|
17.22
|
3.97
|
2013
|
Male
|
2.03
|
7.72
|
15.00
|
16.54
|
20.40
|
8.00
|
|
Female
|
0.46
|
2.94
|
7.11
|
10.75
|
15.17
|
3.69
|
2014
|
Male
|
1.94
|
7.77
|
13.71
|
16.04
|
18.83
|
7.89
|
|
Female
|
0.52
|
2.90
|
6.67
|
9.87
|
14.78
|
3.80
|
2015
|
Male
|
2.11
|
7.41
|
13.41
|
17.27
|
19.65
|
8.66
|
|
Female
|
0.47
|
2.76
|
6.79
|
10.93
|
17.49
|
4.23
|
2016
|
Male
|
2.16
|
7.63
|
14.24
|
14.08
|
18.69
|
8.33
|
|
Female
|
0.44
|
3.59
|
5.73
|
11.05
|
14.60
|
4.11
|
2017
|
Male
|
3.00
|
7.51
|
14.97
|
16.03
|
21.81
|
8.92
|
|
Female
|
0.57
|
2.68
|
6.06
|
9.29
|
17.37
|
4.01
|
2018
|
Male
|
2.58
|
8.81
|
15.05
|
19.71
|
23.35
|
9.34
|
|
Female
|
0.70
|
2.91
|
6.69
|
11.37
|
19.09
|
4.44
|
2019
|
Male
|
2.34
|
7.93
|
15.36
|
19.88
|
21.29
|
9.17
|
|
Female
|
0.33
|
2.51
|
6.78
|
21.57
|
16.64
|
5.18
|
Table 6 Percentages of hyperlipidemia in 2019 of the control group, the 1st and 8th year of the follow-up group
Age group
|
≤40y
|
41-50y
|
51-60y
|
61-70y
|
≥71y
|
Total
|
2019
|
Male
|
21.60
|
27.67
|
27.79
|
19.39
|
12.94
|
23.24
|
|
Female
|
6.79
|
14.39
|
30.61
|
29.59
|
20.98
|
15.33
|
1st
|
Male
|
18.17
|
24.88
|
26.62
|
19.02
|
13.04
|
21.25
|
|
female
|
4.89
|
10.94
|
20.36
|
27.24
|
18.85
|
12.23
|
8th
|
Male
|
22.39#
|
26.88
|
25.00
|
20.35
|
15.77
|
22.67
|
|
Female
|
8.70*,#
|
14.38#
|
24.03#
|
27.52
|
22.56
|
18.10*,#
|
*: p < 0.05 compared with age-matched group in 2019 of the control group
#: p < 0.05 compared with age-matched group in the 1st year of the follow-up group
|
Table 7 Percentages of hyperglycemia in 2019 of the control group, the 1st and 8th year of the follow-up group
Age group
|
≤40y
|
41-50y
|
51-60y
|
61-70y
|
≥71y
|
Total
|
2019
|
Male
|
2.34
|
7.93
|
15.36
|
19.88
|
21.29
|
9.17
|
|
Female
|
0.33
|
2.51
|
6.78
|
11.57
|
16.64
|
5.18
|
1st
|
Male
|
1.67
|
6.22
|
11.27
|
12.20
|
18.26
|
7.35
|
|
Female
|
0.52
|
2.26
|
6.98
|
10.04
|
16.75
|
4.01
|
8th
|
Male
|
2.75
|
8.04
|
13.37
|
21.59#
|
22.52#
|
13.28*,#
|
|
Female
|
0.65*
|
3.54*,#
|
6.87
|
13.92*,#
|
19.78*
|
7.33*,#
|
*: p < 0.001 compared with age-matched group in 2019 of the control group
#: p < 0.001 compared with age-matched group in the 1st year of the follow-up group
|