Ethics approval and consent to participate
Study methods were approved by the institutional review boards at participating institutions and all participants provided written informed consent for the storage of their clinical data for research purposes as part of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) project.
Consent for publication:
Availability of data and materials
Qualified researchers trained in human subject confidentiality protocols may request access to the data that support the findings of this study by contacting the REGARDS Study at [email protected]
The following authors received support for this work:
RSR, MC, PM, TV, SJ, and LDC.
RSR reports research funding to his institution from NIH, Amgen, Arrowhead, Novartis and Regeneron, consulting fees from Amgen, Amryt, C5, CVS Caremark, Novartis and Regneron, non-promotional speaking fees from Amgen, Kowa and Regeneron, royalties from Wolters Kluwer (UpToDate), and stock holdings in MediMergent, LLC.
MC reports NIH grants to institution, Data Safety Monitoring Board or Advisory Board for a CIHR funded clinical trial on statin use in venous thrombosis, unpaid leadership role on Hemostasis and Thrombosis Research Society board, and Journal Editor in Chief stipend from the International Society on Thrombosis and Haemotsasis.
ECM reports Amgen funding to institution.
PM reports NIH funding to institution, Amgen funding to institution, and Amgen consulting fees.
ZW reports no disclosures.
TV reports NIH funding to institution, unrelated Astrazeneca consulting fees, Education event payment from ICOLA 2021 to self, pending patent for LCMSMS method for quantification of Lp(a).
JH reports NIH MPI and NIH PPG grant funding to institution, and expert testimony for a patent case.
CT reports grants to institution, royalties from Wolters Kluwer (UpToDate) to self, educational event payment for Lecture on Nutrition and Parkinson’s Disease to self, and a leadership role in the Arlington Heights Memorial Library Board of Trustees.
SJ reports NIH funding to institution.
LDC reports Amgen funding to institution.
This study was supported by NIH R01AG061186. REGARDS is supported by cooperative agreement U01 NS041588 co-funded by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), National Institutes of Health, Department of Health and Human Service. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NINDS or the NIA. Representatives of the NINDS were involved in the review of the manuscript but were not directly involved in the collection, management, analysis or interpretation of the data.
The individual contributions of authors to the manuscript should be specified in this section. Guidance and criteria for authorship can be found in our editorial policies.
RSR, MC, PM, LDC, JH obtained funding for this research. RSR, MC, EM, PM, TV, CT, SJ, LDC analyzed and interpreted the data and wrote the manuscript, ZW conducted the statistical analyses. All authors read and approved the final manuscript.
We acknowledge Ying Wen for contributing to part of the programming and data analyses, and Priscilla Meija and Shaunte Baboumian for assistance with manuscript preparation. The authors thank the other investigators, the staff, and the participants of the REGARDS study for their valuable contributions. A full list of participating REGARDS investigators and institutions can be found at: https://www.uab.edu/soph/regardsstudy/