[20] Botha et al. (2018), Brain
|
24 CI OAs from MCSA and ADRC
|
Cerebellar crus gray
|
Didn’t say
|
Temporal meta-ROI (amygdala, EC, fusiform, parahippocampal, ITG, MTG)
|
ROC maximizing sensitivity/specificity between YAs and A+ CI OAs
|
1.33
|
[21] Cho et al. (2018), Neurobiol Aging
|
220 OAs (all dx) from memory clinic
|
Cerebellar cortex
|
Yes using region-based voxelwise method (and no)
|
25 individual ROIs
|
Mean + 2.5 SDs above CU with minimal cortical Abeta (<1.4) and EC tau (<1.2)
|
None reported
|
[22] Dodich et al. (2020), Eur J Nucl Med
|
81 CI OAs from memory clinic
|
Cerebellar crus
|
Didn’t say
|
Meta-ROI (medial temporal lobe, lateral occipital, ITG)
|
ROC between A-/N- vs everyone else
|
1.24
|
[23] Guo et al. (2020), Alz Res Ther
|
341 OAs (all dx) from ADNI
|
Inferior cerebellar cortex
|
Yes using GTM
|
1) Temporal meta-ROI (amygdala, EC, fusiform, parahippocampal, ITG, MTG)
2) EC ROI
|
A) ROC with Youden index between A- CU and A+ C
B) Mean +2 SDs above A- CU
|
1A) 1.25
2A) 1.21
1B) 1.34
2B) 1.31
|
[24] Jack et al. (2017), Alz Dem
|
49 YAs and 153 OAs (all dx) from MCSA and ADRC
|
Cerebellar crus gray median
|
“Most likely CSF” voxels were removed
|
Temporal meta-ROI (amygdala, EC, fusiform, parahippocampal, ITG, MTG)
|
1) Maximize specificity (95%) based on YAs
2) Maximize sensitivity (10%) based on A+ CI OAs
3) ROC maximizing accuracy between YAs and A+ CI OAs
4) ROC maximizing accuracy between A- CU OAs and A+ CI OAs
|
1) 1.19
2) 1.21
3) 1.21
4) 1.32
|
[25] Jack et al. (2017), Lancet Neuro
|
435 OAs from MCSA (YAs not reported)
|
Cerebellar crus gray median
|
No
|
Temporal meta-ROI (amygdala, EC, fusiform, parahippocampal, ITG, MTG)
|
ROC maximizing accuracy between YAs and A+ CI OAs
|
1.23
|
[26] Jack et al. (2019), JAMA
|
480 OAs without dementia
from MCSA (YAs not reported)
|
Cerebellar crus gray
|
No (and yes using two compartment method)
|
Temporal meta-ROI (amygdala, EC, fusiform, parahippocampal, ITG, MTG)
|
1) ROC maximizing accuracy between YAs and A+ CI OAs
2) ROC maximizing accuracy between A- CU and A+ CI OAs
|
1) 1.25
2) 1.33
|
[27] Jang et al. (2019), Eur J Nucl Med imaging
|
60 OAs with SVCI from medical center and 49 OAs (all dx) from hospital
|
Cerebellar gray
|
Yes
|
1) Braak V/VI
2) Braak III/IV
3) Braak I/II
|
CIDT (criterion variable unspecified); T+ considered III/IV or above
|
1) 1.58
2) 1.33
3) 1.29
|
[28] Lowe et al. (2018), Alz Dem: DADM
|
112 YAs from MCSA and 576 OAs from MCSA and ADRC
|
Cerebellar Crus
|
No
|
Temporal meta-ROI (EC, parahippocampal, hippocampus); 26 individual ROIs also assessed
|
95% above A- YAs
|
None reported
|
[29] Lowe et al. (2018), Brain
|
98 YAs, 601 A- CU OAs, 86 A+ CI OAs from MCSA and ADRC
|
Cerebellar crus gray
|
No (and yes using two compartment method)
|
47 individual ROIs
|
95% above A- YAs for each ROI
|
None reported
|
[30] Lowe et al. (2019), Neurology
|
117 YAs; 579 CU OAs from MCSA
|
Cerebellar crus
|
No (and yes using GTM)
|
43 individual ROIs
|
95% percent above A- YAs
|
1.17 in EC
|
[31] Lowe et al. (2020), Alz Dem
|
26 OAs from MCSA and ADRC
|
Cerebellar Crus
|
No (and yes using GTM)
|
1) Temporal meta-ROI (amygdala, EC, fusiform, parahippocampal, ITG, MTG)
2) EC ROI
|
ROC with Youden index between AD and non-AD spectrum pathology
|
*
1) 1.29
2) 1.27
|
[32] Maass et al. (2017), Neuroimage
|
Sample 1: 12 YAs, 74 CU OAs from BACS, and 61 CI OAs from ADRC
Sample 2: 42 CU and 28 CI OAs from ADNI
|
Inferior cerebellar gay
|
1)Yes using GTM
2) No
|
A) Temporal meta-ROI
B) ITG
(Also examined whole brain, AD-vulnerable mask, and Braak stage composite regions)
|
ROC with Youden index between A- CU OAs and A+ CI OAs)
(Also used CIDT with age/diagnostic group as input variable for Braak composite staging)
|
1A) 1.47 (BACS/UCSF) and 1.34 (ADNI)
1B) 1.27 (BACS/UCSF) and 1.20 (ADNI)
2A) 1.46 (BACS/UCSF) and 1.40 (ADNI)
2B) 1.30 (BACS/UCSF) and 1.23 (ADNI)
(other cut-points omitted from table but included in results section)
|
[33] Mattsson-Carlgren et al. (2020), Sci Adv
|
131 OAs (all dx) from BioFINDER
|
Inferior cerebellar gray
|
No (and yes using GTM in EC)
|
1) EC
2) ITG
3) Braak V/VI
|
Mean +2 SDs above independent A- CU group
|
1) 1.39
2) 1.31
3) 1.28
|
[34] Meyer et al. (2020), JAMA Neuro
|
322 OAs (all dx) from ADNI
|
Inferior cerebellar gray
|
No (and yes using GTM)
|
Temporal meta-ROI (amygdala, EC, fusiform, parahippocampal, ITG, MTG)
|
ROC with maximum percentage correct classification between A- CU OAs and A+ CI OAs
|
*
1.37
|
[35] Mishra et al. (2017), Neuroimage
|
97 OAs (all dx) from ADRC
|
1) Whole cerebellum
2) Cerebellar cortex
|
Yes using RSF
|
Meta-ROI (EC, lateral occipital, ITG, amygdala)
|
SKM method to cluster into high and low tau groups; midpoint taken
|
1) 1.25
2) 1.22
|
[36] Ossenkoppele et al. (2018), JAMA
|
719 OAs (all dx) from ADRC, BioFINDER, and memory clinic
|
Inferior cerebellar gray
|
No (and
yes using GTM)
|
5 ROIs examined: EC, ITG, temporal meta-ROI, temporoparietal cortex, Braak V/VI
|
1) Mean +2 SDs above CU
2) ROC Youden index between controls and AD
|
*
For temporal meta-ROI:
1)1.34
2)1.27
(other cut-points omitted from table but included in results section)
|
[37] Rafii et al. (2017), JAD
|
9 adults with Down syndrome from DSBI
|
1) Cerebellar cortex (bottom slice removed and edges eroded)
2) subcortical WM
|
Yes using Muller-Gartner method
|
Braak I-VI average
|
Quantitative discrimination of A- vs A+
|
1) 1.2
2) 1.05
|
[38] Schöll et al. (2016), Neuron
|
5 YAs and 33 CU OAs from BACS; 15 CI OAs from ADRC
|
Cerebellar gray
|
Yes using GTM
|
1) Braak V/VI
2) Braak III/IV
3) Braak I/II
|
CIDT using age/diagnostic group as input variable
|
1) 2.79
2) 1.73
3) 1.40
|
[39] Schwarz et al. (2016), Brain
|
14 YAs and 173 OAs (all dx) from a clinical study
|
Cerebellar crus
|
Didn’t say
|
7 ROIs corresponding to Braak histological stages
|
Mean +2.5 SDs above YAs
|
Ranged from 1.22 (STG) to 1.36 (fusiform)
|
[40] Schwarz et al. (2018), Alz Dem
|
14 YA, 21 OAs (all dx) for test-retest, and 98 OAs (all dx) from ADNI
|
Cerebellar gray
|
Didn’t say
|
1) Meta-ROI (hippocampus, TEC, fusiform, MTG, STG, extrastriate, striate)
2) Simplified meta-ROI (medial temporal, lateral temporal, STG, primary visual cortex)
3) Lobar (average temporal, parietal, and frontal lobes) (ROIs gray matter masked)
|
1) Mean +2.5 SDs above T- YAs for each ROI within meta-ROI; T+ is anyone above threshold in hippocampus, TEC, fusiform, MTG, and extrastriate
2) Mean +3 SDs above T- YAs to obtain same average as (1); T+ is anyone above threshold in MTL and lateral temporal
3) Mean +3 SDs above T- YAs to obtain same average as (1); T+ is anyone above threshold in temporal lobe
|
*
1.28
|
[41] Wang et al. (2016), JAMA Neuro
|
59 OAs (all dx) from ADRC
|
Cerebellar cortex
|
No (and yes using linear regression)
|
1) Hippocampus
2) Meta-ROI (medial temporal, ITG, lateral temporal, inferior parietal, PCC, precuneus, SPL)
|
A) ROC with Youden index between A- CU and A+ AD
B) ROC with Youden index between A+ CU and A+ AD
|
*
1A) 1.36
2A) 1.19
1B) 1.36
2B) 1.33
|
[42] Weigand et al. (2020), Brain Comms
|
523 OAs (all dx) from ADNI
|
Inferior cerebellar gray
|
Yes using GTM
|
1) Braak V/VI
2) Braak III/IV
3) Braak I/II
|
CIDT with MMSE as input variable
|
1) 1.96
2) 1.51
3) 1.18
|