Ethical approval, consent to participate and forpublication
We declared that this manuscript is original, has not been published before and is not currently being considered for publication elsewhere.
I affirm that this manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned (and, if relevant, registered) have been explained.
Regarding ethical issues, I verify that the authors had access to relevant aggregated study data and other information (such as study protocol, analytic plan and report, validated data table, and clinical study report) required to understand and report research findings. The authors take responsibility for the presentation and publication of the research findings, have been fully involved at all stages of publication and presentation development, and are willing to take public responsibility for all aspects of the work. All individuals included as authors and contributors who made substantial intellectual contributions to the research, data analysis, and publication or presentation development are listed appropriately. The role of the sponsor in the design, execution, analysis, reporting, and funding is fully disclosed. The authors’ personal interests, financial or non-financial, relating to this research and its publication have been disclosed.
On the other hand, we would like to highlight that we have had permission from all people included in the acknowledgements section to be named in the article. Also, we have obtained a signed consent form from the patient involved in this study. These forms are filed with our records and will be available whenever the journal requires it.
Availability of data and materials
The data that support the findings of this study are available from Igenomix, S. L., but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of Igenomix, S.L.
Conflict of interest and financial disclosure
N.B., E.M., R.P.N., J.B.N., and M.M. are employed by Igenomix, S.L and report no conflicts of interest. The study was financially supported by Igenomix Lab S.L.U.
Author’s contributions
N.B.: collection and assembly of data, data analysis and interpretation, manuscript writing, and final approval of the manuscript; E.M.: collection and assembly of data, data analysis and interpretation, manuscript writing, and final approval of the manuscript; R.P.N.: collection and assembly of data, data analysis and interpretation, manuscript writing, and final approval of the manuscript; J.B.N: collection and assembly of data, data analysis and interpretation, manuscript writing, and final approval of the manuscript; MM: conception and design, collection and assembly of data, data analysis and interpretation, manuscript writing, and final approval of the manuscript.
Acknowledgements
The authors thank all the NIPT staff at Igenomix Spain Lab S.L.U. for their technical support. and Fresh Eyes Editing LLC for editing this manuscript.