Plakin proteins are a family of large cytoskeletal proteins whose primary role is maintaining cytoskeletal integrity, but they are also essential in maintaining the network between cytoskeleton, plasma membrane, and intracellular organelles. Many cancers show increased plakin expression in tumors compared to normal tissue. In fact, in colon and breast cancer, plakins are directly involved in metastatic processes, but they are chronically under-studied in cancer, despite playing such an important role. A recent review explored the roles they play in disease-states, particularly cancers, with an emphasis on ovarian cancer. Ovarian cancer patients are typically not diagnosed until late-stage disease, but plakin proteins show promise as an early-stage biomarker. The current body of research shows crucial plakin expression changes in ovarian cancer progression and recurrence. For example, changes in plakin expression may drive the transition from benign ovarian tumors to carcinomas. While more research is needed to determine the full role plakins play in ovarian cancer and how they may be used as biomarkers, this line of inquiry may lead to better outcomes for ovarian cancer patients.