The authors acknowledge to the staff of the animal facility for their collaboration and especially Dr. C. Castilla for the anesthesia of the animals. Also to Combat Medical company for the transfer of the peritoneal lavage system and especially Mr. Mariano Coronado for his support during the surgeries. We thank Oliver Shaw (Instituto de Investigación Sanitaria-Fundación Jiménez Díaz) for revising the manuscript for aspects related to the English language
M. G-A contributions to the conception and design of the work, drafting the manuscript, data analysis and interpretation, critical review of content, final approval of the version to be published. P.V-C: contributions to the design of the work, performing the experiments, critical review of content, final approval of the version to be published. J. B: data collection, performing the experiments, final approval of the version to be published. S. G. G-H: performing the histological experiments, design of figures, final approval of the version to be published. L. V-C: performing the experiments, data analysis and interpretation, final approval of the version to be published. H. G: performing the experiments, critical revision of the paper, final approval of the version to be published. D. G-O: contributions to the conception and design of the work, performing the experiments, critical review of content, final approval of the version to be published.
Declarations of interest.
Ethics approval and consent to participate: The present study was approved by the Research Ethics Committee of the University Hospital Fundación Jiménez Díaz and Community of Madrid (No.PROEX93.1/20) All experiments were performed following national and international regulations on the protection of experimental animals.
1. I am authorized by my co-authors to enter into these arrangements.
2. I warrant, on behalf of myself and my co-authors, that:
o the article is original, has not been formally published in any other peer-reviewed journal, is not under consideration by any other journal and does not infringe any existing copyright or any other third party rights;
o I am/we are the sole author(s) of the article and have full authority to enter into this agreement and in granting rights to BMC are not in breach of any other obligation;
o the article contains nothing that is unlawful, libellous, or which would, if published, constitute a breach of contract or of confidence or of commitment given to secrecy;
o I/we have taken due care to ensure the integrity of the article. To my/our - and currently accepted scientific - knowledge all statements contained in it purporting to be facts are true and any formula or instruction contained in the article will not, if followed accurately, cause any injury, illness or damage to the user.
3. I, and all co-authors, agree that the article, if editorially accepted for publication, shall be licensed under the Creative Commons Attribution License 4.0. In line with BMC's Open Data Policy, data included in the article shall be made available under the Creative Commons 1.0 Public Domain Dedication waiver, unless otherwise stated. If the law requires that the article be published in the public domain, I/we will notify BMC at the time of submission, and in such cases not only the data but also the article shall be released under the Creative Commons 1.0 Public Domain Dedication waiver. For the avoidance of doubt it is stated that sections 1 and 2 of this license agreement shall apply and prevail regardless of whether the article is published under Creative Commons Attribution License 4.0 or the Creative Commons 1.0 Public Domain Dedication waiver.
Singed: Dr. Mariano García-Arranz
Availability of data and material.
The datasets analysed during the current study available from the corresponding author on reasonable request
Authors D. G-O, M.G-A, H.G, J. B and L V-C have applied for 1 patent related titled “Chemical Scalpel” (EP 19382118.8).
Authors P. V-C and S. G. G-H declare no competing interests.
This study has been funded by grant Instituto de Salud Carlos III (ISCIII) and co-founded by FEDER (PI19/01263).