Ethics approval and consent to participate: This cohort study was approved by Local ethical committees of each cohort center: “Ehtikkomission beider Basel”, “Kantonale Ethikkommission Bern”, “Comité d’Ethique Genève”, “Comission cantonale d’éthique Vaud”, “Comitato etico cantonale Ticino”, “Ethik-Kommission St. Gallen”, and “Kantonale Ethik-Kommission Zürich” and all patients provided written informed consent.
Consent for publication: Not applicable.
Availability of data and materials: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Competing interests: BS reports support to his institution for travel grants from Gilead Sciences outside the submitted work. MC reports support to his institution for expert opinion and/or travel grant from Abbvie, Gilead, MSD and Viiv, and an unrestricted research grant from Gilead and Viiv outside the submitted work. JF reports support to his institution for advisory boards and/or travel grants from and/or unrestricted grants from Abbvie, Gilead Sciences, Janssen-Cilag, MSD, and Viiv-Healthcare. All remuneration was provided outside the submitted work. HF reports unrestricted educational grant supports to his home institution by Gilead Sciences, Viiv, Abbvie, Bristol-Myers Squibb and MSD outside the submitted work. AR reports support to his institution for advisory boards and/or travel grants from Janssen-Cilag, MSD, Gilead Sciences, Abbvie, and Bristol-Myers Squibb, and an unrestricted research grant from Gilead Sciences. All remuneration went to his home institution and not to AR personally, and all remuneration was provided outside the submitted work. GW reports support to his home institution for advisory boards and/or travel grants from MSD, Gilead Sciences and Abbvie, and an unrestricted research grant from Gilead Sciences. All remuneration was provided outside the submitted work.
Funding: This work was funded by the framework of the SHCS, supported by the Swiss National Science Foundation [SNF grant number 177499, SHCS project number 842]. GW was supported by a Professorship from the Swiss National Science Foundation [PP00P3_176944]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Authors’ contributions: BS, AR and GW designed the study, performed statistical analyses and drafted the initial manuscript. MC, AC, JF, MS, EB, BR, CAF, HK and FH contributed to the conception of the study and revised the manuscript for substantial intellectual content. All authors read and approved the final manuscript.
Acknowledgments: We thank all patients, doctors, and nurses associated with the Swiss HIV Cohort Study (SHCS). The members of the SHCS are Anagnostopoulos A, Battegay M, Bernasconi E, Böni J, Braun DL, Bucher HC, Calmy A, Cavassini M, Ciuffi A, Dollenmaier G, Egger M, Elzi L, Fehr J, Fellay J, Furrer H, Fux CA, Günthard HF (President of the SHCS), Haerry D (deputy of "Positive Council"), Hasse B, Hirsch HH, Hoffmann M, Hösli I, Huber M, Kahlert CR (Chairman of the Mother & Child Substudy), Kaiser L, Keiser O, Klimkait T, Kouyos RD, Kovari H, Ledergerber B, Martinetti G, Martinez de Tejada B, Marzolini C, Metzner KJ, Müller N, Nicca D, Paioni P, Pantaleo G, Perreau M, Rauch A (Chairman of the Scientific Board), Rudin C, Scherrer AU (Head of Data Centre), Schmid P, Speck R, Stöckle M (Chairman of the Clinical and Laboratory Committee), Tarr P, Trkola A, Vernazza P, Wandeler G, Weber R, Yerly S.