This research integrated the circular economy (CE) concept in the cassava starch industry in Thailand, and revealed the benefits of biogas generation from both the wastewater and waste cassava pulp with a focus on the identification and analysis of the key drivers and challenges to increase the efficiency of the biogas system. The research methodology applied the CE concept for scenarios of cassava pulp utilization for biogas production, compared to the no waste treatment and anaerobic wastewater treatment scenarios, in termsof an economic assessment, resource efficiency, water recovery, land use, and global warming potential. Proposed options mainly involved the conservation of energy, water, land use, and reduction of greenhouse gases emissions. These included the reuse and recycling of water and use of biogas to substitute for fuel oil for burners and electricity in the cassava starch production process.