See the published version of this preprint at Nutrition Journal.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Xiang Gao
the Pennsylvania State University, University Park
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2617-6509
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Inconsistent associations between egg consumption and cardiovascular disease (CVD) risk have been observed in previous studies. This study aims to longitudinally investigate the association between egg consumption and altered risk of arterial stiffness, a major pre-clinical pathogenic change of CVD, which was assessed by brachial-ankle pulse wave velocity (baPWV).
Methods
A total of 7,315 Chinese participants from the Kailuan Study, free of CVD and cancer were included in this study. Egg consumption was assessed by a semi-quantitative validated food frequency questionnaire in 2014. baPWV was repeatedly measured at baseline and during follow-up (mean follow-up: 3.41 years). General linear regression was used to calculate means of baPWV change rate across different egg consumption groups, adjusting for age, sex, baseline baPWV, healthy eating index, total energy, social-economic status, blood pressure, obesity, smoking, lipid profiles, and fasting glucose concentrations.
Results
Compared to the annual baPWV change rate in participants with 0-1.9 eggs/wk (adjusted mean: 35.9 ± 11.2 cm/s/y), those consuming 3-3.9 eggs/wk (adjusted mean: 0.2 ± 11.4 cm/s/y) had the lowest increase in baPWV during follow-up (P-difference = 0.002). Individuals with low (0-1.9 eggs/wk) vs. high (5 + eggs /wk) egg intake showed similar changes in baPWV.
Conclusions
In this large-scale longitudinal analysis, we did not find a significant difference in arterial stiffness, as assessed by baPWV level, between low and high egg consumption groups. However, moderate egg consumption (3-3.9 eggs/wk) appeared to have beneficial effects on arterial stiffness.
Keywords
Egg consumption, arterial stiffness, cardiovascular disease, longitudinal study
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CURRENT STATUS: Published
View the published article at Nutrition Journal.
Version 1
Posted 08 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 22 Mar, 2021
Review #2 received
Received 17 Mar, 2021
Reviewer #2 agreed
On 16 Mar, 2021
Review #1 received
Received 07 Feb, 2021
Reviewers invited
Invitations sent on 28 Jan, 2021
Reviewer #1 agreed
On 28 Jan, 2021
Editor assigned
On 25 Dec, 2020
Submission checks complete
On 25 Dec, 2020
Editor invited
On 25 Dec, 2020
First submitted
On 22 Dec, 2020
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Subject Areas
Nutrition & Dietetics
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See the published version of this preprint at Nutrition Journal.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Xiang Gao
the Pennsylvania State University, University Park
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2617-6509
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Nutrition Journal.
Version 1
Posted 08 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 22 Mar, 2021
Review #2 received
Received 17 Mar, 2021
Reviewer #2 agreed
On 16 Mar, 2021
Review #1 received
Received 07 Feb, 2021
Reviewers invited
Invitations sent on 28 Jan, 2021
Reviewer #1 agreed
On 28 Jan, 2021
Editor assigned
On 25 Dec, 2020
Submission checks complete
On 25 Dec, 2020
Editor invited
On 25 Dec, 2020
First submitted
On 22 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Nutrition Journal.
Background
Inconsistent associations between egg consumption and cardiovascular disease (CVD) risk have been observed in previous studies. This study aims to longitudinally investigate the association between egg consumption and altered risk of arterial stiffness, a major pre-clinical pathogenic change of CVD, which was assessed by brachial-ankle pulse wave velocity (baPWV).
Methods
A total of 7,315 Chinese participants from the Kailuan Study, free of CVD and cancer were included in this study. Egg consumption was assessed by a semi-quantitative validated food frequency questionnaire in 2014. baPWV was repeatedly measured at baseline and during follow-up (mean follow-up: 3.41 years). General linear regression was used to calculate means of baPWV change rate across different egg consumption groups, adjusting for age, sex, baseline baPWV, healthy eating index, total energy, social-economic status, blood pressure, obesity, smoking, lipid profiles, and fasting glucose concentrations.
Results
Compared to the annual baPWV change rate in participants with 0-1.9 eggs/wk (adjusted mean: 35.9 ± 11.2 cm/s/y), those consuming 3-3.9 eggs/wk (adjusted mean: 0.2 ± 11.4 cm/s/y) had the lowest increase in baPWV during follow-up (P-difference = 0.002). Individuals with low (0-1.9 eggs/wk) vs. high (5 + eggs /wk) egg intake showed similar changes in baPWV.
Conclusions
In this large-scale longitudinal analysis, we did not find a significant difference in arterial stiffness, as assessed by baPWV level, between low and high egg consumption groups. However, moderate egg consumption (3-3.9 eggs/wk) appeared to have beneficial effects on arterial stiffness.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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