This preprint is under consideration at Nutrition Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Amir Abbasnezhad
Lorestan University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9436-7334
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Pathophysiology of IBS is not well recognized; however, several studies have shown the possible relationship between diet and risk of IBS. We assessed the ability of the dietary inflammatory index (DII) to predict the risk of IBS.
Methods
The subjects were 155 IBS cases and 310 age- and sex-matched healthy controls. IBS was recognized using the Rome IV criteria. DII score was computed based on dietary intake using a 168-item FFQ. The FFQ was analyzed using Nutritionist ІV. The DII score was calculated based on energy-adjusted amounts of nutrients using residual method. Logistic regression models were used to estimate multivariable odds ratios (ORs).
Results
The mean DII score was significantly higher among IBS patients in comparison to healthy controls (0.78 ± 2.22 vs. -0.39 ± 2.27). In crude model, increase in DII as continuous variable was associated with a significant increase in the risk of IBS (OR (95% CI): 1.26 (1.1-15.38)). Furthermore, the association remained significant even after adjusting for age and sex (OR (95% CI): 1.28 (1.1-17.41)) and after multivariate adjustment (OR (95% CI): 1.38 (1.2-1.56)). In crude, age and sex adjusted and multivariate-adjusted models subjects in fourth quartile of DII had higher OR in comparison to subjects in first quartile.
Conclusions
The results of this study showed a possible positive association between a pro-inflammatory diet and the risk of IBS. Thus, encouraging intake of more anti-inflammatory dietary factors and reducing intake of pro-inflammatory factors may be a strategy for reducing risk of IBS.
Keywords
Dietary assessment, Inflammation, dietary inflammatory index (DII), Irritable Bowel Syndrome (IBS)
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Peer Review Timeline
CURRENT STATUS: Under Review
Version (no preprint)
Posted 03 Jun, 2021
Editorial decision: Minor revision
On 03 Jun, 2021
Submission checks complete
On 24 May, 2021
Editor invited
On 24 May, 2021
Review #1 received
Received 22 May, 2021
Review #2 received
Received 17 May, 2021
Reviewer #2 agreed
On 11 May, 2021
Reviews received
Received 11 May, 2021
Reviewers invited
Invitations sent on 10 May, 2021
Editor assigned
On 10 May, 2021
Reviewer #1 agreed
On 10 May, 2021
First submitted
On 06 May, 2021
This version was not preprinted
Version (no preprint)
Posted 25 May, 2021
This version was not preprinted
Version (no preprint)
Posted 17 May, 2021
Review #2 received
Received 17 May, 2021
Reviewer #2 agreed
On 11 May, 2021
Editor assigned
On 10 May, 2021
Reviewers invited
Invitations sent on 10 May, 2021
Reviewer #1 agreed
On 10 May, 2021
Submission checks complete
On 10 May, 2021
Editor invited
On 10 May, 2021
This version was not preprinted
Version 1
Posted 09 Feb, 2021
No community comments so far
Editorial decision: Minor revision
On 18 Apr, 2021
Review #2 received
Received 14 Apr, 2021
Review #3 received
Received 14 Apr, 2021
Reviewer #3 agreed
On 24 Mar, 2021
Review #1 received
Received 11 Mar, 2021
Reviewer #2 agreed
On 18 Feb, 2021
Reviewers invited
Invitations sent on 16 Feb, 2021
Reviews received
Received 16 Feb, 2021
Reviewer #1 agreed
On 16 Feb, 2021
Editor assigned
On 31 Jan, 2021
Submission checks complete
On 31 Jan, 2021
Editor invited
On 31 Jan, 2021
First submitted
On 28 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
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This preprint is under consideration at Nutrition Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Amir Abbasnezhad
Lorestan University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9436-7334
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version (no preprint)
Posted 03 Jun, 2021
Editorial decision: Minor revision
On 03 Jun, 2021
Submission checks complete
On 24 May, 2021
Editor invited
On 24 May, 2021
Review #1 received
Received 22 May, 2021
Review #2 received
Received 17 May, 2021
Reviewer #2 agreed
On 11 May, 2021
Reviews received
Received 11 May, 2021
Reviewers invited
Invitations sent on 10 May, 2021
Editor assigned
On 10 May, 2021
Reviewer #1 agreed
On 10 May, 2021
First submitted
On 06 May, 2021
This version was not preprinted
Version (no preprint)
Posted 25 May, 2021
This version was not preprinted
Version (no preprint)
Posted 17 May, 2021
Review #2 received
Received 17 May, 2021
Reviewer #2 agreed
On 11 May, 2021
Editor assigned
On 10 May, 2021
Reviewers invited
Invitations sent on 10 May, 2021
Reviewer #1 agreed
On 10 May, 2021
Submission checks complete
On 10 May, 2021
Editor invited
On 10 May, 2021
This version was not preprinted
Version 1
Posted 09 Feb, 2021
No community comments so far
Editorial decision: Minor revision
On 18 Apr, 2021
Review #2 received
Received 14 Apr, 2021
Review #3 received
Received 14 Apr, 2021
Reviewer #3 agreed
On 24 Mar, 2021
Review #1 received
Received 11 Mar, 2021
Reviewer #2 agreed
On 18 Feb, 2021
Reviewers invited
Invitations sent on 16 Feb, 2021
Reviews received
Received 16 Feb, 2021
Reviewer #1 agreed
On 16 Feb, 2021
Editor assigned
On 31 Jan, 2021
Submission checks complete
On 31 Jan, 2021
Editor invited
On 31 Jan, 2021
First submitted
On 28 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Pathophysiology of IBS is not well recognized; however, several studies have shown the possible relationship between diet and risk of IBS. We assessed the ability of the dietary inflammatory index (DII) to predict the risk of IBS.
Methods
The subjects were 155 IBS cases and 310 age- and sex-matched healthy controls. IBS was recognized using the Rome IV criteria. DII score was computed based on dietary intake using a 168-item FFQ. The FFQ was analyzed using Nutritionist ІV. The DII score was calculated based on energy-adjusted amounts of nutrients using residual method. Logistic regression models were used to estimate multivariable odds ratios (ORs).
Results
The mean DII score was significantly higher among IBS patients in comparison to healthy controls (0.78 ± 2.22 vs. -0.39 ± 2.27). In crude model, increase in DII as continuous variable was associated with a significant increase in the risk of IBS (OR (95% CI): 1.26 (1.1-15.38)). Furthermore, the association remained significant even after adjusting for age and sex (OR (95% CI): 1.28 (1.1-17.41)) and after multivariate adjustment (OR (95% CI): 1.38 (1.2-1.56)). In crude, age and sex adjusted and multivariate-adjusted models subjects in fourth quartile of DII had higher OR in comparison to subjects in first quartile.
Conclusions
The results of this study showed a possible positive association between a pro-inflammatory diet and the risk of IBS. Thus, encouraging intake of more anti-inflammatory dietary factors and reducing intake of pro-inflammatory factors may be a strategy for reducing risk of IBS.
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