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Research note
Khadijeh Mirzaei
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7554-8551
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives
Associations are present between insulin resistance (IR) and dyslipidemia and cardiometabolic factors. Caveolin-1 (CAV1) is involved in glucose/lipid homeostasis and may modulate IR signaling. We investigated the relationship between CAV1 and IR signaling in modulating dyslipidemia and fat composition in overweight and obese women with a prevalent variant in the CAV1 gene.
Results
There were no statistical differences in FPG, plasma insulin, and HOMA-IR (p > 0.05) between CAV1 variants. Individuals with AA and AG alleles were slightly older and had higher BMI, FMI, and VLF values; and tended to have lower total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) (p < 0.05). HOMA-IR levels predicted fat mass index (FMI) 0.47 (0.08,0.87), visceral fat level (VFL) 0.65 (0.23,1.07), TC 6.82 (1.76,11.88) and HDL-C -1.663 (-3.11, -0.214) only between minor allele carriers in unadjusted and adjusted models. (, CI (P < 0.01). Our r
Keywords
Caveolin-1, Insulin Resistance, Dyslipidemia, Polymorphism, Obesity
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 04 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 15 Mar, 2021
Reviewer #1 agreed
On 13 Mar, 2021
Review #1 received
Received 13 Mar, 2021
Reviewers invited
Invitations sent on 13 Feb, 2021
Editor assigned
On 10 Feb, 2021
Submission checks complete
On 10 Feb, 2021
Editor invited
On 10 Feb, 2021
First submitted
On 24 Dec, 2020
Metrics
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PDF Downloads: ...
HTML Views: ...
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This preprint is under consideration at BMC Research Notes. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
Khadijeh Mirzaei
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7554-8551
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 04 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 15 Mar, 2021
Reviewer #1 agreed
On 13 Mar, 2021
Review #1 received
Received 13 Mar, 2021
Reviewers invited
Invitations sent on 13 Feb, 2021
Editor assigned
On 10 Feb, 2021
Submission checks complete
On 10 Feb, 2021
Editor invited
On 10 Feb, 2021
First submitted
On 24 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives
Associations are present between insulin resistance (IR) and dyslipidemia and cardiometabolic factors. Caveolin-1 (CAV1) is involved in glucose/lipid homeostasis and may modulate IR signaling. We investigated the relationship between CAV1 and IR signaling in modulating dyslipidemia and fat composition in overweight and obese women with a prevalent variant in the CAV1 gene.
Results
There were no statistical differences in FPG, plasma insulin, and HOMA-IR (p > 0.05) between CAV1 variants. Individuals with AA and AG alleles were slightly older and had higher BMI, FMI, and VLF values; and tended to have lower total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) (p < 0.05). HOMA-IR levels predicted fat mass index (FMI) 0.47 (0.08,0.87), visceral fat level (VFL) 0.65 (0.23,1.07), TC 6.82 (1.76,11.88) and HDL-C -1.663 (-3.11, -0.214) only between minor allele carriers in unadjusted and adjusted models. (, CI (P < 0.01). Our r
Figure 1
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