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Research Article
BERRAK DUMLUPINAR ALTINSOY
Istanbul Gelisim Universitesi
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0898-3043
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Aim
The synthesis of nanosilver particles (AgNPs) from Pelargonium quercetorum Agnew. (Geraniaceae) and evaluation of the antimicrobial and the cytotoxic potential of AgNPs.
Materials & Methods
The synthesized AgNPs were evaluated for antimicrobial and anticancer efficacy using the minimum inhibition concentration method and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide) assay.
Results
The AgNPs inhibited approximately 90% the growth of gram-positive Staphylococcus aureus and gram-negative Esherichia coli and yeast Candida albicans pathogens at a concentration of 500 µg/mL. The synthesized AgNPs showed excellent toxicity in MCF-7 cells, and specifically, pq70 AgNP inhibited the growth of MCF-7 cells by 52% at a concentration of 3.125 µg/mL.
Conclusion
It was determined that the AgNPs, which had been synthesized from extracts that contained a high phenolic composition, were smaller in size, and showed high anticancer and antimicrobial properties.
Keywords
Pelargonium quercetorum, Geraniaceae, silver nanoparticle, antimicrobial, cytotoxicity
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 26 Mar, 2021
No community comments so far
Review #2 received
Received 12 Apr, 2021
Review #1 received
Received 12 Apr, 2021
Reviewer #3 agreed
On 11 Apr, 2021
Reviewer #2 agreed
On 06 Apr, 2021
Reviewer #1 agreed
On 29 Mar, 2021
Reviewers invited
Invitations sent on 23 Mar, 2021
Editor assigned
On 23 Mar, 2021
Submission checks complete
On 23 Mar, 2021
Editor invited
On 23 Mar, 2021
First submitted
On 16 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
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This preprint is under consideration at Bioresources and Bioprocessing. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
BERRAK DUMLUPINAR ALTINSOY
Istanbul Gelisim Universitesi
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0898-3043
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 26 Mar, 2021
No community comments so far
Review #2 received
Received 12 Apr, 2021
Review #1 received
Received 12 Apr, 2021
Reviewer #3 agreed
On 11 Apr, 2021
Reviewer #2 agreed
On 06 Apr, 2021
Reviewer #1 agreed
On 29 Mar, 2021
Reviewers invited
Invitations sent on 23 Mar, 2021
Editor assigned
On 23 Mar, 2021
Submission checks complete
On 23 Mar, 2021
Editor invited
On 23 Mar, 2021
First submitted
On 16 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Aim
The synthesis of nanosilver particles (AgNPs) from Pelargonium quercetorum Agnew. (Geraniaceae) and evaluation of the antimicrobial and the cytotoxic potential of AgNPs.
Materials & Methods
The synthesized AgNPs were evaluated for antimicrobial and anticancer efficacy using the minimum inhibition concentration method and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide) assay.
Results
The AgNPs inhibited approximately 90% the growth of gram-positive Staphylococcus aureus and gram-negative Esherichia coli and yeast Candida albicans pathogens at a concentration of 500 µg/mL. The synthesized AgNPs showed excellent toxicity in MCF-7 cells, and specifically, pq70 AgNP inhibited the growth of MCF-7 cells by 52% at a concentration of 3.125 µg/mL.
Conclusion
It was determined that the AgNPs, which had been synthesized from extracts that contained a high phenolic composition, were smaller in size, and showed high anticancer and antimicrobial properties.
Figure 1
Figure 2
Figure 3
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