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Research article
Omidreza Salehi
University of Kurdistan
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5328-4658
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Studies have shown that exercises and the use of natural foods have favorable effects on Alzheimer's disease (AD). The purpose of this study was to investigate the effects of resistance training (RT) with royal jelly (RJ) on serotonin and dopamine receptors expression in hippocampal tissue of rats with AD.
Methods
In this experimental study, 56 rats with AD were randomly divided into (1) control, (2) RT, (3) RT + 100 mg/kg RJ, 4) RT + 200 mg/kg RJ, 5) 100 mg/kg RJ, 6) 200 mg/kg RJ2 and 7) sham. Also in order to review the effects of AD induction on serotonin and dopamine, 8 healthy rats selected as healthy control group. During 8 weeks the groups 3, 4, 5 and 6 received daily RJ with specific doses peritoneally and groups 2, 3 and 4 performed RT three sessions per week with 30–100 percentage of body weight. Independent sample t- test, One way ANOVA and two-way ANOVA was used to investigate the effect of RT, RJ and interaction of RT and RJ also Bonferroni’s post- hoc test was used to evaluate the difference between the doses of RJ using SPSS software (P ≤ 0.05).
Results
RT had a significant effect on the increase of dopamine (p = 0.001) and serotonin receptors (p = 0.001); RJ had a significant effect on the increase of dopamine receptor(p = 0.01) and serotonin (p = 0.001) also RT simultaneously with RJ consumption had a significant interactive effect on the increase of serotonin receptor (p = 0.001).
Conclusion
It appears that RT and RJ can enhance serotonergic and dopaminergic function in hippocampal tissue of rats with AD, however, the effects of RJ seems to be dose dependent.
Keywords
Training, Royal Jelly, Serotonin, Dopamine, Alzheimer's Disease
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This is a preprint. It has not completed peer review.
Research article
Omidreza Salehi
University of Kurdistan
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5328-4658
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 22 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Studies have shown that exercises and the use of natural foods have favorable effects on Alzheimer's disease (AD). The purpose of this study was to investigate the effects of resistance training (RT) with royal jelly (RJ) on serotonin and dopamine receptors expression in hippocampal tissue of rats with AD.
Methods
In this experimental study, 56 rats with AD were randomly divided into (1) control, (2) RT, (3) RT + 100 mg/kg RJ, 4) RT + 200 mg/kg RJ, 5) 100 mg/kg RJ, 6) 200 mg/kg RJ2 and 7) sham. Also in order to review the effects of AD induction on serotonin and dopamine, 8 healthy rats selected as healthy control group. During 8 weeks the groups 3, 4, 5 and 6 received daily RJ with specific doses peritoneally and groups 2, 3 and 4 performed RT three sessions per week with 30–100 percentage of body weight. Independent sample t- test, One way ANOVA and two-way ANOVA was used to investigate the effect of RT, RJ and interaction of RT and RJ also Bonferroni’s post- hoc test was used to evaluate the difference between the doses of RJ using SPSS software (P ≤ 0.05).
Results
RT had a significant effect on the increase of dopamine (p = 0.001) and serotonin receptors (p = 0.001); RJ had a significant effect on the increase of dopamine receptor(p = 0.01) and serotonin (p = 0.001) also RT simultaneously with RJ consumption had a significant interactive effect on the increase of serotonin receptor (p = 0.001).
Conclusion
It appears that RT and RJ can enhance serotonergic and dopaminergic function in hippocampal tissue of rats with AD, however, the effects of RJ seems to be dose dependent.
Figure 1
Figure 2
Figure 3
Figure 4
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