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Research note
Mahmoud Djalali
Tehran University of Medical Sciences
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Objective
The purpose of this clinical trial was to examine the effect of omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels and gene expression of VCAM in patients with episodic migraine.
Results
In this study, 80 patients were randomly divided in to 4 groups to receive for 2 months. Both serum levels and gene expression of VCAM showed remarkable decreases after single W-3 and after combined W-3 and nanocurcumin interventions. However, a borderline significant change and no remarkable change were observed after single nanocurcumin supplementation and in control group, respectively. While a significant difference between study groups in VCAM concentrations existed, there was no meaningful difference in VCAM gene expression among groups. It appears that the W-3 and combined W-3 and nanocurcumin can relieve VCAM serum level and its gene expression in patients with episodic migraine. Moreover, the combination of W-3 with nanocurcumin might cause more significant declines in VCAM level in the serum of migraine patients than when W-3 is administered alone.
Keywords
Migraine, vascular cell adhesion molecule, gene expression, serum concentration, omega-3, nanocurcumin
This is a list of supplementary files associated with this preprint. Click to download.
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CURRENT STATUS: Published
View the published article at BMC Research Notes.
Version 1
Posted 19 Apr, 2021
No community comments so far
Review #1 received
Received 03 May, 2021
Editorial decision: Minor revision
On 03 May, 2021
Reviewers invited
Invitations sent on 15 Apr, 2021
Reviewer #1 agreed
On 15 Apr, 2021
Editor assigned
On 14 Apr, 2021
Submission checks complete
On 14 Apr, 2021
Editor invited
On 14 Apr, 2021
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Research Notes.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
Mahmoud Djalali
Tehran University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Research Notes.
Version 1
Posted 19 Apr, 2021
No community comments so far
Review #1 received
Received 03 May, 2021
Editorial decision: Minor revision
On 03 May, 2021
Reviewers invited
Invitations sent on 15 Apr, 2021
Reviewer #1 agreed
On 15 Apr, 2021
Editor assigned
On 14 Apr, 2021
Submission checks complete
On 14 Apr, 2021
Editor invited
On 14 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Research Notes.
Objective
The purpose of this clinical trial was to examine the effect of omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels and gene expression of VCAM in patients with episodic migraine.
Results
In this study, 80 patients were randomly divided in to 4 groups to receive for 2 months. Both serum levels and gene expression of VCAM showed remarkable decreases after single W-3 and after combined W-3 and nanocurcumin interventions. However, a borderline significant change and no remarkable change were observed after single nanocurcumin supplementation and in control group, respectively. While a significant difference between study groups in VCAM concentrations existed, there was no meaningful difference in VCAM gene expression among groups. It appears that the W-3 and combined W-3 and nanocurcumin can relieve VCAM serum level and its gene expression in patients with episodic migraine. Moreover, the combination of W-3 with nanocurcumin might cause more significant declines in VCAM level in the serum of migraine patients than when W-3 is administered alone.
This is a list of supplementary files associated with this preprint. Click to download.
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