We aimed to compare the human genome with the olive genome on the hypothetical context of whether or not any human-plant genomic alignment similarities could give rise to genomic bioavailability when consumed likewise carbohydrates, proteins, fats. Many studies from past to present have shown beneficial effects of olives on cardiovascular diseases and some cancer pathways. Moreover, scientific and even religious resources highlighted the importance of the olive. In our project, we aligned the olive genome with the human genome in Pubmed Blast database. We detected several genes has had 100 percent matching sequences where pathological and non-pathological variations were identified in the human genome. Interestingly wild type variations were observed in the olive genome and those matching regions were consuming restriction sites. In our data, matching regions at cardiovascular and cancer-related genes could suggest a possible bioavailability of plant genomes even in vitro. Further studies, comparing other plant genomes with the human genome would beget more promising results.