This paper studies a stochastic differential equation SIS epidemic model, disturbed randomly by the mean-reverting Ornstein-Uhlenbeck process and Brownian motion. We prove the existence and uniqueness of the positive global solutions of the model and obtain the controlling conditions for the extinction and persistence of the disease. The results show that when the basic reproduction number Rs0 < 1, the disease will extinct, on the contrary, when the basic reproduction number Rs0 > 1, the disease will persist. Furthermore, we can inhibit the outbreak of the disease by increasing the intensity of volatility or decreasing the speed of reversion ϑ, respectively. Finally, we give some numerical examples to verify these results.