1. Chakraborty S and Newton AC. Climate change, plant diseases and food security: an overview. Plant Pathol. 2011; 60: 2-14.
2. Yang K, Qin Q, Liu Y, Zhang L, Liang L, Lan H, et al. Adenylate cyclase acya regulates development, aflatoxin biosynthesis and fungal virulence in Aspergillus flavus. Front Cell Infect. Microbiol. 2016; 6: 190.
3. Hahn M. The rising threat of fungicide resistance in plant pathogenic fungi: Botrytis as a case study. J. Chem. Biol. 2014; 7: 133-141.
4. Wegulo SN, Zwingman MV, Breathnach JA and Baenziger PS. Economic returns from fungicide application to control foliar fungal diseases in winter wheat. Crop Prot. 2011; 30: 685-692.
5. De Miccolis Angelini RM, Rotolo C, Masiello M, Gerin D, Pollastro S and Faretra F. Occurrence of fungicide resistance in populations of Botryotinia fuckeliana (Botrytis cinerea) on table grape and strawberry in southern Italy. Pest Manage Sci. 2014; 70: 1785-1796.
6. Gomez AO, Mattner SW, Oag D, Nimmo P, Milinkovic M and Villalta ON. Protecting fungicide chemistry used in Australian strawberry production for more sustainable control of powdery mildew and leaf blotch. Acta. Hortic. 2016; 1156: 735-742.
7. Cooper TF, Ostrowski EA and Travisano M. A negative relationship between mutation pleiotropy and fitness effect in yeast. Evolution. 2007; 61: 1495-1499.
8. Hall AR, Angst DC, Schiessl KT and Ackermann M. Costs of antibiotic resistance-separating trait effects and selective effects. Evol. Appl. 2015; 8: 261-272.
9. Karaoglanidis GS and Thanassoulopoulos CC. Cross-resistance patterns among sterol biosynthesis inhibiting fungicides (SBIs) in Cercospora beticola. Eur. J. Plant Pathol. 2003; 109: 929-934.
10. Chowdhary A, Kathuria S, Xu J and Meis JF. Emergence of azole-resistant Aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human health. PLoS Pathog. 2013; 9: e1003633.
11. Avenot HF, Solorio C, Morgan DP and Michailides TJ. Sensitivity and cross-resistance patterns to demethylation-inhibiting fungicides in California populations of Alternaria alternata pathogenic on pistachio. Crop. Prot. 2016; 88: 72-78.
12. Malandrakis AA, Apostolidou ZA, Markoglou A and Flouri F. Fitness and cross-resistance of Alternaria alternata field isolates with specific or multiple resistance to single site inhibitors and mancozeb. Eur. J. Plant Pathol. 2015; 142: 489-499.
13. Leroux P and Walker AS. Activity of fungicides and modulators of membrane drug transporters in field strains of Botrytis cinerea displaying multidrug resistance. Eur. J. Plant Pathol. 2013; 135: 683-693.
14. Omrane S, Sghyer H, Audéon C, Lanen C, Duplaix C, Walker AS, et al. Fungicide efflux and the MgMFS1 transporter contribute to the multidrug resistance phenotype in Zymoseptoria tritici field isolates. Environ. Microbiol. 2015; 17: 2805-2823.
15. Gullino ML, Tinivella F, Garibaldi A, Kemmitt GM, Bacci L and Sheppard B. (2010). Mancozeb: past, present, and future. Plant Dis. 2010; 94: 1076-1087.
16. Munkvold GP. Seed pathology progress in academia and industry. Annu. Rev. Phytopathol. 2009; 47: 285-311.
17. Dias PJ, Teixeira MC, Telo JP and Sá-Correia I. Insights into the mechanisms of toxicity and tolerance to the agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approach. OMICS: J. Integr. Biol. 2010; 14: 211-227.
18. Leroux P and Walker AS. Multiple mechanisms account for resistance to sterol 14α-demethylation inhibitors in field isolates of Mycosphaerella graminicola. Pest Manage Sci. 2011; 67: 44-59.
19. Thomas A, Langston JrDB. and Stevenson KL. Baseline sensitivity and cross-resistance to succinate-dehydrogenase-inhibiting and demethylation-inhibiting fungicides in Didymella bryoniae. Plant Dis. 2012; 96: 979-984.
20. Villani SM, Biggs AR, Cooley DR, Raes JJ and Cox KD. Prevalence of myclobutanil resistance and difenoconazole insensitivity in populations of Venturia inaequalis. Plant Dis. 2015; 99: 1526-1536.
21. Van der Waals JE, Korsten L and Aveling TAS. A review of early blight of potato. African Plant Prot. 2001; 7, 91-102.
22. Leiminger JH and Hausladen H. Early blight control in potato using disease-orientated threshold values. Plant Dis. 2012; 96: 124-130.
23. Rodrigues TTMS, Berbee ML, Simmons EG, Cardoso CR, Reis A, Maffia LA, and Mizubuti ESG. (2010). First report of Alternaria tomatophila and A. grandis causing early blight on tomato and potato in Brazil. New Disease Reports. 2010; 22: 28.
24. Zheng HH, Zhao J, Wang TY and Wu XH. Characterization of Alternaria species associated with potato foliar diseases in China. Plant Pathol. 2015; 64: 425-433.
25. Meng JW, Zhu W, He MH, Wu , Duan GH, Xie YK, et al. Population genetic analysis reveals cryptic sex in the phytopathogenic fungus Alternaria alternata. Sci. Rep. 2015; 5: 18250.
26. Meng JW, He DC, Zhu W, Yang LN, Wu E, Xie JH, et al. Human-mediated gene flow contributes to metapopulation genetic structure of the pathogenic fungus Alternaria alternata from Potato. Frontiers in Plant Science. 2018; 9: 198.
27. Zhan J, Stefanato FL and McDonald BA. Selection for increased cyproconazole tolerance in Mycosphaerella graminicola through local adaptation and in response to host resistance. Mol. Plant Pathol. 2006; 7: 259-268.
28. He MH, Li DL, Zhu W, Wu EJ, Yang LN, Wang YP, et al. Slow and temperature-mediated pathogen adaptation to a non-specific fungicide in agricultural ecosystem. Evol. Appl. 2018; 11: 182-192.
29. Lamari L. Assess: image analysis software for plant disease quantification. USA: The American Phytopathological Society Press. 2002.
30. Aguayo J, Elegbede F, Husson C, Saintonge FX and Marçais B. (2014). Modeling climate impact on an emerging disease, the Phytophthora alni-induced alder decline. Global Change Biol. 2014; 20: 3209-3221.
31. Brunner PC, Stefansson TS, Fountaine J, Richina V and McDonald BA. A global analysis of cyp51 diversity and azole sensitivity in Rhynchosporium commune. Phytopathology. 2016; 106: 355-361.
32. Kokalis-Burelle N, Butler DM and Rosskopf EN. Evaluation of cover crops with potential for use in anaerobic soil disinfestation (ASD) for susceptibility to three species of Meloidogyne. J. Nematol. 2013; 45: 272-278.
33. Lawrence I and Lin K. (1989). A concordance correlation coefficient to evaluate reproducibility. Biometrics. 1989; 45: 255-268.
34. Jiang L. Application of MATLAB-based regression analysis model in enterprises. Appl. Mech. Mater. 2013; 328: 239-243.
35. Sun X, Wang J, Feng D, Ma Z and Li H. PdCYP51B, a new putative sterol 14α-demethylase gene of Penicillium digitatum involved in resistance to imazalil and other fungicides inhibiting ergosterol synthesis. Appl. Microbiol. Biotechnol. 2011; 91: 1107-1119.
36. Villani SM, Hulvey J, Hily JM and Cox KD. Overexpression of the CYP51A1 gene and repeated elements are associated with differential sensitivity to DMI fungicides in Venturia inaequalis. Phytopathol. 2016; 106: 562-571.
37. Kasmi S, Bkhairia I, Harrabi B, Mnif H, Marrakchi R, Ghozzi H, et al. Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250. Toxicol. Mech. Methods. 2018: 28: 12-22.
38. De Waard MA. Resistance to fungicides which inhibit sterol 14ademethylation, an historical perspective. (UK BCPC, Farnham), 1994. p, 3-10.
39. Sebaugh, J. L. (2011). Guidelines for accurate EC50/IC50 estimation. Pharm. Stat. 2011; 10: 128-134.
40. Elliott M, Shamoun SF and Sumampong G. Effects of systemic and contact fungicides on life stages and symptom expression of Phytophthora ramorum in vitro and in planta. Crop Prot. 2015; 67: 136-144.
41. Kojima KI and Schaffer HE. Survival process of linked mutant gene. Evolution. 1967; 21: 518-531.
42. Maynard-Smith J and Haigh J. (1974). The hitch-hiking effect of a favourable gene. Genet. Res. 1974; 23: 23-35.
43. Wang Y, Lim L, DiGuistini S, Robertson G, Bohlmann J and Breuil C. A specialized ABC efflux transporter GcABC-G1 confers monoterpene resistance to Grosmannia clavigera, a bark beetle-associated fungal pathogen of pine trees. New Phytol. 2013; 197: 886-898.
44. Hayashi K, Schoonbeek HJ and De Waard MA. Bcmfs1, a novel major facilitator superfamily transporter from Botrytis cinerea, provides tolerance towards the natural toxic compounds camptothecin and cercosporin and towards fungicides. Appl. Environ. Microbiol. 2002; 68: 4996-5004.
45. Youngchim S, Morris-Jones R, Hay RJ and Hamilton AJ. Production of melanin by Aspergillus fumigatus. J. Med. Microbiol. 2004; 53: 175-181.
46. Ngamskulrungroj P and Meyer W. (2009). Melanin production at 37°C is linked to the high virulent Cryptococcus gattii Vancouver Island outbreak genotype VGIIa. Austr. Mycol. 2009; 28: 9-14,
47. Liaw SJ, Lee YL and Hsueh PR. Multidrug resistance in clinical isolates of Stenotrophomonas maltophilia: roles of integrons, efux pumps, phosphoglucomutase (SpgM), and melanin and biofilm formation. Intl. J. Antimicrobial Agents. 2010; 35: 126-130.
48. Cousin A, Mehrabi R, Guilleroux M, Dufresne M, Van der Lee T, Waalwijk C, et al. (2006). The MAP kinase-encoding gene MgFus3 of the non-appressorium phytopathogen Mycosphaerella graminicola is required for penetration and in vitro pycnidia formation. Mol. Plant Pathol. 2006; 7: 269-278.
49. Cordero RJ, and Casadevall A. Functions of fungal melanin beyond virulence. Fungal Biology Reviews. 2017; 31: 99-112.
50. Kawamura C, Moriwaki J, Kimura N, Fujita Y, Fuji SI, Hirano T, et al. The melanin biosynthesis genes of Alternaria alternata can restore pathogenicity of the melanin-deficient mutants of Magnaporthe grisea. Mol. Plant-microbe Interact. 1997; 10: 446-453.
51. Yago JI, Lin CH and Chung KR. The SLT2 jhggfmitogen-activated protein kinase-mediated signalling pathway governs conidiation, morphogenesis, fungal virulence and production of toxin and melanin in the tangerine pathotype of Alternaria alternata. Mol. Plant Pathol. 2011; 12: 653-665.
52. Chen LH, Lin CH and Chung KR. A nonribosomal peptide synthetase mediates siderophore production and virulence in the citrus fungal pathogen Alternaria alternata. Mol. Plant. Pathol. 2013; 14: 497-505.
53. Cowen LE, Nantel A, Whiteway MS, Thomas DY, Tessier DC, Kohn LM, & Anderson JB. (2002). Population genomics of drug resistance in Candida albicans. Proc. Natl. Acad. Sci USA 2002; 99: 9284-9289.
54. Sellam A, Dongo A, Guillemette T, Hudhomme P and Simoneau P. Transcriptional responses to exposure to the brassicaceous defence metabolites camalexin and allyl-isothiocyanate in the necrotrophic fungus Alternaria brassicicola. Mol. Plant Pathol. 2007; 8: 195-208.
55. Gagneux S, Long CD, Small PM, Van T, Schoolnik GK and Bohannan BJ. The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science 2006; 312: 1944-1946.
56. Billard A, Fillinger S, Leroux P, Lachaise H, Beffa R and Debieu D. Strong resistance to the fungicide fenhexamid entails a fitness cost in Botrytis cinerea, as shown by comparisons of isogenic strains. Pest Manage Sci. 2012; 68: 684-691.
57. Yang L, Gao F, Shang L, Zhan J and McDonald BA. Association between virulence and triazole tolerance in the phytopathogenic fungus Mycosphaerella graminicola. PLoS One 2013; 8: e59568.
58. Jones JDG and Dang JL. The plant immune system. Nature. 2006; 444: 323-329.
59. Anderson JB, Sirjusingh C, Parsons AB, Boone C, Wickens C, Cowen LE, & Kohn LM. Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 2003; 163: 1287-1298.
60. Fernandes C, Prados-Rosales R, Silva BM, Nakouzi-Naranjo A, Zuzarte M, Chatterjee S, et al. Activation of melanin synthesis in Alternaria infectoria by antifungal drugs. Antimicrob. Agents. Ch. 2016; 60: 1646-1655.
61. Zhan J, Thrall PH, Papaïx J, Xie L and Burdon JJ. Playing on a pathogen's weakness: using evolution to guide sustainable plant disease control strategies. Annu. Rev. Phytopathol. 2015; 53: 19-43.