Single-cell Landscape of Malignant Transition: Unraveling Cancer Cell-of-Origin and Heterogeneous Tissue Microenvironment
Assessing the distribution of cancer stem cells in tumorspheres
Metformin reduces the clonal fitness of Dnmt3aR878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state
Glioma stem cells deliver ABCB4 transcribed by ATF3 via exosomes conferring glioma resistance to temozolomide
Substrate stiffness mediates osteogenic and adipogenic differentiation of osteosarcoma through the PIEZO1 / ITGB1 -YAP -EZH2 signaling pathway
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma
Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells
Establishment of a Small-cell Lung Cancer (SCLC) Mouse Model Using Enhanced Cancer Stem Cell–functioning 3D SCLC Spheroids
Glycolysis-mTORC1 crosstalk drives rapid proliferation in patient-derived endometrial cancer spheroids with ALDH activity
Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport