MS-CETSA functional proteomics uncovers new DNA-repair programs leading to Gemcitabine resistance
Cysteine allostery and autoinhibition govern human STING oligomer functionality
Morphological and genetic screens reveal mechanisms of BiDAC-induced plasma membrane protein degradation
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy
The combination of IFNα2b/5-FU inhibits proliferation and cell cycle of tumor cells in treating Ocular Surface Squamous Neoplasia
Loganin ameliorates acetaminophen-induced acute liver injury via targeting TOP1MT-mediated hepatocyte apoptosis and ferroptosis
Structure-aware machine learning strategies for antimicrobial peptide discovery
SAG1.3-derived Frizzled-targeting negative allosteric modulators
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket
Venetoclax triggers sub-lethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine